ID B2UND0_AKKM8 Unreviewed; 281 AA. AC B2UND0; DT 01-JUL-2008, integrated into UniProtKB/TrEMBL. DT 01-JUL-2008, sequence version 1. DT 10-FEB-2009, entry version 7. DE SubName: Full=Pantoate/beta-alanine ligase; DE EC=6.3.2.1; GN OrderedLocusNames=Amuc_0404; OS Akkermansia muciniphila (strain ATCC BAA-835). OC Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales; OC Verrucomicrobiaceae; Akkermansia. OX NCBI_TaxID=349741; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., RA Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., RA Ivanova N., Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., RA de Vos W.M., Richardson P.; RT "Complete sequence of Akkermansia muciniphila ATCC BAA-835."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the condensation of pantoate with beta-alanine CC in an ATP-dependent reaction via a pantoyl-adenylate intermediate. CC -!- CATALYTIC ACTIVITY: ATP + (R)-pantoate + beta-alanine = AMP + CC diphosphate + (R)-pantothenate. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001071; ACD04242.1; -; Genomic_DNA. DR RefSeq; YP_001877023.1; -. DR GeneID; 6274820; -. DR GenomeReviews; CP001071_GR; Amuc_0404. DR KEGG; amu:Amuc_0404; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004592; F:pantoate-beta-alanine ligase activity; IEA:InterPro. DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro. DR InterPro; IPR003721; Pantoate_ligase. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1. DR PANTHER; PTHR21299:SF1; Pantoate_ligase; 1. DR Pfam; PF02569; Pantoate_ligase; 1. DR TIGRFAMs; TIGR00018; panC; 1. PE 4: Predicted; KW ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; KW Pantothenate biosynthesis. SQ SEQUENCE 281 AA; 30917 MW; CC39BF5AD725D307 CRC64; MQTFSTKAQL RAALLKHHRK HDHVVLVPTM GALHAGHRAL LEQARKLAGE DGVVVASIFV NPIQFNNSSD LQTYPRTPEK DLEVCEGAGV DYVFSPAPEE MYSGERSIAV EESFLSATLC GASRPGHFSG VCTVLAKLFN LVQPTDAIFG KKDYQQLAII RRMVRDLDFP VRIHGAEIVR HGNGLAYSSR NARLTPEQKE QAVVIRQAML QARDEFQAGA DASKVKEHAA AMIEGVPGTR IDYLEIVDAE TMQPVAENRK PALMAAAVYF GDVRLIDNIE L //