ID B2RCY5_HUMAN Unreviewed; 633 AA. AC B2RCY5; DT 01-JUL-2008, integrated into UniProtKB/TrEMBL. DT 01-JUL-2008, sequence version 1. DT 24-JAN-2024, entry version 70. DE SubName: Full=cDNA, FLJ96373, highly similar to Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA {ECO:0000313|EMBL:BAG37732.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG37732.1}; RN [1] {ECO:0000313|EMBL:BAG37732.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta {ECO:0000313|EMBL:BAG37732.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., RA Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., RA Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., RA Isogai T.; RT "NEDO functional analysis of protein and research application project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315332; BAG37732.1; -; mRNA. DR RefSeq; NP_006288.2; NM_006297.2. DR AlphaFoldDB; B2RCY5; -. DR PeptideAtlas; B2RCY5; -. DR DNASU; 7515; -. DR GeneID; 7515; -. DR KEGG; hsa:7515; -. DR CTD; 7515; -. DR PharmGKB; PA369; -. DR OrthoDB; 1334125at2759; -. DR BioGRID-ORCS; 7515; 128 hits in 1163 CRISPR screens. DR GenomeRNAi; 7515; -. DR Genevisible; B2RCY5; HS. DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt. DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro. DR GO; GO:0006284; P:base-excision repair; IEA:InterPro. DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. DR GO; GO:0000012; P:single strand break repair; IEA:InterPro. DR CDD; cd17725; BRCT_XRCC1_rpt1; 1. DR CDD; cd17707; BRCT_XRCC1_rpt2; 1. DR Gene3D; 3.40.50.10190; BRCT domain; 2. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1. DR InterPro; IPR001357; BRCT_dom. DR InterPro; IPR036420; BRCT_dom_sf. DR InterPro; IPR045080; BRCT_XRCC1_rpt1. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR002706; Xrcc1_N. DR PANTHER; PTHR11370:SF5; DNA REPAIR PROTEIN XRCC1; 1. DR PANTHER; PTHR11370; DNA-REPAIR PROTEIN XRCC1; 1. DR Pfam; PF00533; BRCT; 1. DR Pfam; PF16589; BRCT_2; 1. DR Pfam; PF01834; XRCC1_N; 1. DR SMART; SM00292; BRCT; 2. DR SUPFAM; SSF52113; BRCT domain; 2. DR SUPFAM; SSF49785; Galactose-binding domain-like; 1. DR PROSITE; PS50172; BRCT; 2. PE 2: Evidence at transcript level; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 315..403 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT DOMAIN 538..629 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT REGION 221..314 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 400..462 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 471..490 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 498..536 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 221..239 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 240..256 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 263..283 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 428..444 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 633 AA; 69537 MW; 123BEA5277A3ACF0 CRC64; MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTH TPATAPVPAR AQGAVTGKPR GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL ICAFANTPKY SQVLGLGSRI VRKEWVLDCH RMRRRLPSRR YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA //