ID B2RCY5_HUMAN Unreviewed; 633 AA. AC B2RCY5; DT 01-JUL-2008, integrated into UniProtKB/TrEMBL. DT 01-JUL-2008, sequence version 1. DT 17-JUN-2020, entry version 58. DE SubName: Full=cDNA, FLJ96373, highly similar to Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA {ECO:0000313|EMBL:BAG37732.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG37732.1}; RN [1] {ECO:0000313|EMBL:BAG37732.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta {ECO:0000313|EMBL:BAG37732.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., RA Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., RA Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., RA Isogai T.; RT "NEDO functional analysis of protein and research application project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315332; BAG37732.1; -; mRNA. DR RefSeq; NP_006288.2; NM_006297.2. DR PeptideAtlas; B2RCY5; -. DR PRIDE; B2RCY5; -. DR GeneID; 7515; -. DR KEGG; hsa:7515; -. DR CTD; 7515; -. DR PharmGKB; PA369; -. DR eggNOG; KOG3226; Eukaryota. DR eggNOG; ENOG410ZE1H; LUCA. DR KO; K10803; -. DR OrthoDB; 539462at2759; -. DR SignaLink; B2RCY5; -. DR BioGRID-ORCS; 7515; 87 hits in 790 CRISPR screens. DR GenomeRNAi; 7515; -. DR Genevisible; B2RCY5; HS. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro. DR GO; GO:0000012; P:single strand break repair; IEA:InterPro. DR Gene3D; 2.60.120.260; -; 1. DR Gene3D; 3.40.50.10190; -; 2. DR InterPro; IPR001357; BRCT_dom. DR InterPro; IPR036420; BRCT_dom_sf. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR002706; Xrcc1_N. DR Pfam; PF00533; BRCT; 1. DR Pfam; PF16589; BRCT_2; 1. DR Pfam; PF01834; XRCC1_N; 1. DR SMART; SM00292; BRCT; 2. DR SUPFAM; SSF49785; SSF49785; 1. DR SUPFAM; SSF52113; SSF52113; 2. DR PROSITE; PS50172; BRCT; 2. PE 2: Evidence at transcript level; FT DOMAIN 315..403 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT DOMAIN 538..629 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT REGION 221..314 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 400..462 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 471..490 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 498..536 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 221..239 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 240..256 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 263..283 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 428..444 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 633 AA; 69537 MW; 123BEA5277A3ACF0 CRC64; MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTH TPATAPVPAR AQGAVTGKPR GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL ICAFANTPKY SQVLGLGSRI VRKEWVLDCH RMRRRLPSRR YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA //