ID B2LID8_9TELE Unreviewed; 217 AA. AC B2LID8; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 16-MAY-2012, entry version 18. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Exoglossum maxillingua. OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Exoglossum. OX NCBI_TaxID=86944; RN [1] RP NUCLEOTIDE SEQUENCE. RA Hubert N., Hanner R., Holm E., Mandrak N.E., Taylor E., Burridge M., RA Watkinson D., Dumont P., Curry A., Bentzen P., Zhang J., April J., RA Bernatchez L.; RT "Identifying Canadian freshwater fishes through DNA barcodes."; RL PLoS ONE 3:e2490-e2490(2008). RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=21670289; DOI=10.1073/pnas.1016437108; RA April J., Mayden R.L., Hanner R.H., Bernatchez L.; RT "Genetic calibration of species diversity among North America's RT freshwater fishes."; RL Proc. Natl. Acad. Sci. U.S.A. 108:10602-10607(2011). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU524057; ACC92099.1; -; Genomic_DNA. DR EMBL; EU524613; ACC92655.1; -; Genomic_DNA. DR EMBL; EU524616; ACC92658.1; -; Genomic_DNA. DR EMBL; JN026609; AEK03233.1; -; Genomic_DNA. DR EMBL; JN026610; AEK03234.1; -; Genomic_DNA. DR EMBL; JN026611; AEK03235.1; -; Genomic_DNA. DR EMBL; JN026612; AEK03236.1; -; Genomic_DNA. DR EMBL; JN026614; AEK03238.1; -; Genomic_DNA. DR HOVERGEN; HBG102108; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR InterPro; IPR000883; Cyt_c_Oxase_su1. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; COX1; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 217 217 SQ SEQUENCE 217 AA; 23059 MW; 7DF036F206D0DC8B CRC64; LYLVFGAWAG MVGTALSLLI RAELSQPGSL LGDDQIYNVI VTAHAFVMIF FMVMPILIGG FGNWLVPLMI GAPDMAFPRM NNMSFWLLPP SFLLLLASSG VEAGAGTGWT VYPPLAGNLA HAGASVDLTI FSLHLAGVSS ILGAVNFITT IINMKPPAIS QYQTPLFVWA VLVTAVLLLL SLPVLAAGIT MLLTDRNLNT TFFDPAGGGD PILYQHL //