ID B2L8Q6_HORBR Unreviewed; 196 AA. AC B2L8Q6; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 16-JAN-2019, entry version 23. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003297}; DE Flags: Fragment; GN Name=ND4 {ECO:0000313|EMBL:ACB72971.1}; OS Horabagrus brachysoma (Gunther's catfish) (Pseudobagrus brachysoma). OG Mitochondrion {ECO:0000313|EMBL:ACB72971.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Bagridae; Horabagrus. OX NCBI_TaxID=337739 {ECO:0000313|EMBL:ACB72971.1}; RN [1] {ECO:0000313|EMBL:ACB72971.1} RP NUCLEOTIDE SEQUENCE. RA Sullivan J.P., Peng Z., Peng J., He S., Lundberg J.G.; RT "Molecular evidence for a non-monophyletic Asian catfish family RT Amblycipitidae and an all-Asian Sisoroidea (Siluriformes: RT Teleostei)."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003297}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003297}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU490815; ACB72971.1; -; Genomic_DNA. DR HOVERGEN; HBG093667; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003297}; KW Membrane {ECO:0000256|RuleBase:RU003297}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:ACB72971.1}; NAD {ECO:0000256|RuleBase:RU003297}; KW Respiratory chain {ECO:0000256|RuleBase:RU003297}; KW Transmembrane {ECO:0000256|RuleBase:RU003297}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003297}; KW Transport {ECO:0000256|RuleBase:RU003297}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 22 40 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 46 66 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 87 106 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 126 151 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 172 195 Helical. {ECO:0000256|RuleBase:RU003297}. FT DOMAIN 1 140 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT NON_TER 1 1 {ECO:0000313|EMBL:ACB72971.1}. SQ SEQUENCE 196 AA; 21869 MW; FD89CBCE395FAD85 CRC64; LALWGVIMTG SICLRQTDLK SLIAYSSVSH MGLVAGGILI QTPWGFTGAL ILMIAHGLVS SALFCLANTT YERTHSRTMV LARGLQIIFP LTATWWFIAN LANLALPPLP NLMGELVIIT AMFNWSPWTL AMTGAGTLIT AAYSLYLFLM TQRGPLPQHI INLQPFHTRE HLLMTLHLLP IILLITKPEI MWGWWY //