ID B2KJ46_CANPA Unreviewed; 279 AA. AC B2KJ46; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 03-AUG-2022, entry version 68. DE SubName: Full=Carbonyl Reductase {ECO:0000313|PDB:3CTM}; DE EC=1.1.1.- {ECO:0000313|PDB:3CTM}; DE SubName: Full=S-reductase {ECO:0000313|EMBL:ABG57118.1}; DE Flags: Fragment; GN ORFNames=DQ675534 {ECO:0000313|PDB:3CTM}; OS Candida parapsilosis (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=5480 {ECO:0000313|EMBL:ABG57118.1}; RN [1] {ECO:0000313|EMBL:ABG57118.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CCTCCM 20311 {ECO:0000313|EMBL:ABG57118.1}; RX PubMed=17435004; DOI=10.1128/AEM.02185-06; RA Nie Y., Xu Y., Mu X.Q., Wang H.Y., Yang M., Xiao R.; RT "Purification, characterization, gene cloning, and expression of a novel RT alcohol dehydrogenase with anti-prelog stereospecificity from Candida RT parapsilosis."; RL Appl. Environ. Microbiol. 73:3759-3764(2007). RN [2] {ECO:0000313|PDB:3CTM, ECO:0007829|PDB:3CTM} RP X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS). RX PubMed=18566346; DOI=10.1110/ps.035089.108; RA Zhang R., Zhu G., Zhang W., Cao S., Ou X., Li X., Bartlam M., Xu Y., RA Zhang X.C., Rao Z.; RT "Crystal structure of a carbonyl reductase from Candida parapsilosis with RT anti-Prelog stereospecificity."; RL Protein Sci. 17:1412-1423(2008). RN [3] {ECO:0007829|PDB:7DLD, ECO:0007829|PDB:7DLM} RP X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS). RA Li Y.H., Zhang R.Z., Forouhar F., Wang C., Montelione G.T., Szyperski T., RA Xu Y., Hunt J.F.; RT "Crystal structures of (S)-carbonyl reductases from Candida parapsilosis in RT different oligomerization states."; RL Submitted (NOV-2020) to the PDB data bank. RN [4] {ECO:0007829|PDB:7VYQ} RP STRUCTURE BY ELECTRON MICROSCOPY (3.13 ANGSTROMS). RA Li Y.H., Zhang R.Z., Wang C., Forouhar F., Clarke O., Vorobiev S., RA Singh S., Montelione G.T., Szyperski T., Xu Y., Hunt J.F.; RT "Oligomeric interactions maintain active-site structure in a non- RT cooperative enzyme family."; RL Submitted (NOV-2021) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ675534; ABG57118.1; -; Genomic_DNA. DR PDB; 3CTM; X-ray; 2.69 A; A/B/C/D/E/F/G/H=1-279. DR PDB; 7DLD; X-ray; 1.75 A; A/B=1-279. DR PDB; 7DLM; X-ray; 1.59 A; A/B=1-279. DR PDB; 7DN1; X-ray; 1.74 A; A=1-279. DR PDB; 7VYQ; EM; 3.13 A; A/B/F/G=1-279. DR PDBsum; 3CTM; -. DR VEuPathDB; FungiDB:CPAR2_501160; -. DR BRENDA; 1.1.1.1; 1133. DR BRENDA; 1.1.1.184; 1133. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR002347; SDR_fam. DR PRINTS; PR00081; GDHRDH. DR PRINTS; PR00080; SDRFAMILY. DR SUPFAM; SSF51735; SSF51735; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:3CTM, ECO:0007829|PDB:7DLD}. FT NON_TER 279 FT /evidence="ECO:0000313|EMBL:ABG57118.1" SQ SEQUENCE 279 AA; 30089 MW; A7E94F2DF6E4A6B0 CRC64; MGEIESYCNK ELGPLPTKAP TLSKNVLDLF SLKGKVASVT GSSGGIGWAV AEAYAQAGAD VAIWYNSHPA DEKAEHLQKT YGVHSKAYKC NISDPKSVEE TISQQEKDFG TIDVFVANAG VTWTQGPEID VDNYDSWNKI ISVDLNGVYY CSHNIGKIFK KNGKGSLIIT SSISGKIVNI PQLQAPYNTA KAACTHLAKS LAIEWAPFAR VNTISPGYID TDITDFASKD MKAKWWQLTP LGREGLTQEL VGGYLYLASN ASTFTTGSDV VIDGGYTCP //