ID B2GV36_RAT Unreviewed; 551 AA. AC B2GV36; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 26-FEB-2020, entry version 93. DE SubName: Full=Slc22a13 protein {ECO:0000313|EMBL:AAI66511.1}; DE SubName: Full=Solute carrier family 22 member 13 {ECO:0000313|Ensembl:ENSRNOP00000075628}; GN Name=Slc22a13 {ECO:0000313|EMBL:AAI66511.1, GN ECO:0000313|Ensembl:ENSRNOP00000075628, ECO:0000313|RGD:1306840}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI66511.1}; RN [1] {ECO:0000313|EMBL:AAI66511.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAI66511.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000075628, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075628, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000075628} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075628}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABR07071731; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07071732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07071733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07073459; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC166511; AAI66511.1; -; mRNA. DR RefSeq; NP_001119757.1; NM_001126285.1. DR RefSeq; XP_008764899.1; XM_008766677.2. DR STRING; 10116.ENSRNOP00000048781; -. DR Ensembl; ENSRNOT00000078303; ENSRNOP00000075628; ENSRNOG00000056476. DR GeneID; 316062; -. DR KEGG; rno:316062; -. DR UCSC; RGD:1306840; rat. DR CTD; 9390; -. DR RGD; 1306840; Slc22a13. DR eggNOG; KOG0255; Eukaryota. DR eggNOG; COG0477; LUCA. DR GeneTree; ENSGT00940000154607; -. DR HOGENOM; CLU_001265_33_3_1; -. DR KO; K08209; -. DR OMA; FPMETRA; -. DR OrthoDB; 704438at2759; -. DR TreeFam; TF315847; -. DR Reactome; R-RNO-197264; Nicotinamide salvaging. DR Proteomes; UP000002494; Chromosome 8. DR Bgee; ENSRNOG00000056476; Expressed in adult mammalian kidney and 6 other tissues. DR Genevisible; B2GV36; RN. DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0090416; F:nicotinate transmembrane transporter activity; ISO:RGD. DR GO; GO:2001142; P:nicotinate transport; ISO:RGD. DR GO; GO:0015747; P:urate transport; ISO:RGD. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR005829; Sugar_transporter_CS. DR Pfam; PF00083; Sugar_tr; 1. DR SUPFAM; SSF103473; SSF103473; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|SAAS:SAAS00297419, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00297396, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00462530, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 21..44 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 143..162 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 169..188 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 194..213 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 225..246 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 252..271 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 333..351 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 363..379 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 391..411 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 417..440 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 452..473 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 479..499 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 21..504 FT /note="MFS" FT /evidence="ECO:0000259|PROSITE:PS50850" FT REGION 515..537 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 551 AA; 60691 MW; 0A0EDFF2BF2DA3CC CRC64; MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LSAFFVFSQV FMVLDEAHYC SVSWVKNHTF NLSAAEQLAV SIPNDTAGRP ESCLMFRPPP DNASLEDILS HRFNETQACD SGWDYPENRP PSLKNEFDLV CERENLKRTS QSVFMAGLLV GALVFGPVCD WIGRRPSLLM QLLLSGIASM ATAFVSSFEL YMTLRFALAT ANAGFLLSSN VLLSEWVGTS RRTRAMVLAQ SNFALGLMAL AGLAYGVRNW RLLQIIGTTP IFLLVFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR PLASELLNQL VPEKTGPSGN ALDLFRHPQL RKVTLILIAV WFVDSLLYYG LGFQVGDFGL DIYLTQVIFG VVEVPARLSS IPMMEKLGRK WSQLCTLTLA GVMCVIIIFI PGDLPTVATA LAVVGKFASS AAFTISYVYT AELLPTIIRQ TGMGLVSIFS RVGGIITPLV MLLEQYHKAI PMLIFGSLPI GAGLLCALLP ETRGQTLKDT LQDLEQGQPP RSYKTAPQRK DVEASGRTSS ARVAVVRSSY F //