ID B2GV36_RAT Unreviewed; 551 AA. AC B2GV36; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 16-JAN-2019, entry version 87. DE SubName: Full=Slc22a13 protein {ECO:0000313|EMBL:AAI66511.1}; DE SubName: Full=Solute carrier family 22 member 13 {ECO:0000313|Ensembl:ENSRNOP00000075628}; GN Name=Slc22a13 {ECO:0000313|EMBL:AAI66511.1, GN ECO:0000313|Ensembl:ENSRNOP00000075628, ECO:0000313|RGD:1306840}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI66511.1}; RN [1] {ECO:0000313|EMBL:AAI66511.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAI66511.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000075628, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075628, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000075628} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075628}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABR07071731; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07071732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07071733; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07073459; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC166511; AAI66511.1; -; mRNA. DR RefSeq; NP_001119757.1; NM_001126285.1. DR RefSeq; XP_008764899.1; XM_008766677.2. DR UniGene; Rn.99291; -. DR STRING; 10116.ENSRNOP00000048781; -. DR Ensembl; ENSRNOT00000078303; ENSRNOP00000075628; ENSRNOG00000056476. DR GeneID; 316062; -. DR KEGG; rno:316062; -. DR UCSC; RGD:1306840; rat. DR CTD; 9390; -. DR RGD; 1306840; Slc22a13. DR eggNOG; KOG0255; Eukaryota. DR eggNOG; COG0477; LUCA. DR GeneTree; ENSGT00940000154607; -. DR HOGENOM; HOG000234569; -. DR HOVERGEN; HBG108433; -. DR KO; K08209; -. DR OMA; PCLMFRP; -. DR OrthoDB; 704438at2759; -. DR TreeFam; TF315847; -. DR Reactome; R-RNO-197264; Nicotinamide salvaging. DR Proteomes; UP000002494; Chromosome 8. DR Bgee; ENSRNOG00000056476; Expressed in 7 organ(s), highest expression level in adult mammalian kidney. DR Genevisible; B2GV36; RN. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro. DR CDD; cd06174; MFS; 1. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR005829; Sugar_transporter_CS. DR Pfam; PF00083; Sugar_tr; 1. DR SUPFAM; SSF103473; SSF103473; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|SAAS:SAAS00768619, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|SAAS:SAAS00768556, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00768702, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 21 44 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 143 162 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 169 188 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 213 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 225 246 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 252 271 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 333 351 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 363 379 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 391 411 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 417 440 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 452 473 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 479 499 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 21 504 MFS. {ECO:0000259|PROSITE:PS50850}. SQ SEQUENCE 551 AA; 60691 MW; 0A0EDFF2BF2DA3CC CRC64; MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LSAFFVFSQV FMVLDEAHYC SVSWVKNHTF NLSAAEQLAV SIPNDTAGRP ESCLMFRPPP DNASLEDILS HRFNETQACD SGWDYPENRP PSLKNEFDLV CERENLKRTS QSVFMAGLLV GALVFGPVCD WIGRRPSLLM QLLLSGIASM ATAFVSSFEL YMTLRFALAT ANAGFLLSSN VLLSEWVGTS RRTRAMVLAQ SNFALGLMAL AGLAYGVRNW RLLQIIGTTP IFLLVFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR PLASELLNQL VPEKTGPSGN ALDLFRHPQL RKVTLILIAV WFVDSLLYYG LGFQVGDFGL DIYLTQVIFG VVEVPARLSS IPMMEKLGRK WSQLCTLTLA GVMCVIIIFI PGDLPTVATA LAVVGKFASS AAFTISYVYT AELLPTIIRQ TGMGLVSIFS RVGGIITPLV MLLEQYHKAI PMLIFGSLPI GAGLLCALLP ETRGQTLKDT LQDLEQGQPP RSYKTAPQRK DVEASGRTSS ARVAVVRSSY F //