ID B2GTA5_DANRE Unreviewed; 445 AA. AC B2GTA5; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 22-FEB-2023, entry version 60. DE RecName: Full=Protein kinase C and casein kinase substrate in neurons protein 1 {ECO:0000256|ARBA:ARBA00013843}; GN Name=pacsin1 {ECO:0000313|EMBL:AAI65817.1}; GN OrderedLocusNames=pacsin1b {ECO:0000313|ZFIN:ZDB-GENE-050913-35}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65817.1}; RN [1] {ECO:0000313|EMBL:AAI65817.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65817.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection, CC ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm, cytosol CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004284}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. Synapse, synaptosome CC {ECO:0000256|ARBA:ARBA00034102}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC165817; AAI65817.1; -; mRNA. DR RefSeq; NP_001028900.1; NM_001033728.1. DR RefSeq; XP_005166197.1; XM_005166140.2. DR RefSeq; XP_009301003.1; XM_009302728.2. DR AlphaFoldDB; B2GTA5; -. DR SMR; B2GTA5; -. DR Ensembl; ENSDART00000056830; ENSDARP00000056829; ENSDARG00000042128. DR Ensembl; ENSDART00000128456; ENSDARP00000107643; ENSDARG00000042128. DR Ensembl; ENSDART00000162469; ENSDARP00000136926; ENSDARG00000042128. DR GeneID; 619246; -. DR KEGG; dre:619246; -. DR CTD; 619246; -. DR ZFIN; ZDB-GENE-050913-35; pacsin1b. DR HOGENOM; CLU_030752_0_0_1; -. DR OMA; WAAIMTE; -. DR OrthoDB; 9421at2759; -. DR PhylomeDB; B2GTA5; -. DR ExpressionAtlas; B2GTA5; baseline and differential. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW. DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell. DR GO; GO:0007015; P:actin filament organization; IEA:InterPro. DR GO; GO:0048666; P:neuron development; IEA:InterPro. DR GO; GO:0097320; P:plasma membrane tubulation; IEA:InterPro. DR CDD; cd07680; F-BAR_PACSIN1; 1. DR CDD; cd11998; SH3_PACSIN1-2; 1. DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR031160; F_BAR. DR InterPro; IPR001060; FCH_dom. DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3. DR InterPro; IPR037454; PACSIN1_F-BAR. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1. DR PANTHER; PTHR23065:SF16; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1; 1. DR Pfam; PF00611; FCH; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00055; FCH; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF103657; BAR/IMD domain-like; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS51741; F_BAR; 1. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE- KW ProRule:PRU01077}; Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}; KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}. FT DOMAIN 12..282 FT /note="F-BAR" FT /evidence="ECO:0000259|PROSITE:PS51741" FT DOMAIN 386..445 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT REGION 327..390 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 187..218 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 327..381 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 445 AA; 51356 MW; 53552263222290C5 CRC64; MSGAYDESAM SDETTDSFWE VGNYKRTVKR IEDGHRLCND MMSCIQERAK IEKAYSQQLT DWSKRWRQLV ERGPQYGTLE RAWLAVMTEA EKVSELHQEV KNNLLNEDLE KVKNWQKDAY HKQMMGGFKE TKEADEGFRK AQKPWAKKLK ELETAKKTYH MACKEEKIAS AREANSKGEA SVTTDQQKKL QEKVDKCKND VQKAKEKYEK SLDELNKCTP QYMENMEVVF DQCQQFEEKR LNFLREVLLD TKRHLNLTES QSYATVYREL ERTIVSASAQ EDLKWFSSVH GPGMHMNWPQ FEEFNPDLSH AISKKEKVKR NHDGVTLTQV THGAEHGTPQ TGDRGSVSSY EKNQQYSAEW SDDEQPPTAA QSASETNGGN PFEEDSKGVR VRALYDYEGQ EQDELTFKAG DELTKLEDED EQGWCKGRLD SGQLGLYPAN YVEPV //