ID B2GTA5_DANRE Unreviewed; 445 AA. AC B2GTA5; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 02-DEC-2020, entry version 50. DE RecName: Full=Protein kinase C and casein kinase substrate in neurons protein 1 {ECO:0000256|ARBA:ARBA00013843}; GN Name=pacsin1b {ECO:0000313|ZFIN:ZDB-GENE-050913-35}; GN Synonyms=pacsin1 {ECO:0000313|EMBL:AAI65817.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65817.1}; RN [1] {ECO:0000313|EMBL:AAI65817.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65817.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, synaptosome CC {ECO:0000256|ARBA:ARBA00004113}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004413}. Cell projection, ruffle membrane CC {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004284}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC165817; AAI65817.1; -; mRNA. DR RefSeq; NP_001028900.1; NM_001033728.1. DR RefSeq; XP_005166197.1; XM_005166140.2. DR RefSeq; XP_009301003.1; XM_009302728.2. DR SMR; B2GTA5; -. DR GeneID; 619246; -. DR KEGG; dre:619246; -. DR CTD; 619246; -. DR ZFIN; ZDB-GENE-050913-35; pacsin1b. DR HOGENOM; CLU_030752_0_0_1; -. DR OMA; NDLMSCV; -. DR OrthoDB; 727724at2759; -. DR PhylomeDB; B2GTA5; -. DR Bgee; ENSDARG00000042128; Expressed in retina and 34 other tissues. DR ExpressionAtlas; B2GTA5; baseline. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell. DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW. DR GO; GO:0007015; P:actin filament organization; IEA:InterPro. DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW. DR GO; GO:0048666; P:neuron development; IEA:InterPro. DR GO; GO:0097320; P:plasma membrane tubulation; IEA:InterPro. DR CDD; cd07680; F-BAR_PACSIN1; 1. DR CDD; cd11998; SH3_PACSIN1-2; 1. DR Gene3D; 1.20.1270.60; -; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR031160; F_BAR. DR InterPro; IPR001060; FCH_dom. DR InterPro; IPR028518; PACSIN1. DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3. DR InterPro; IPR037454; PACSIN1_F-BAR. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23065:SF16; PTHR23065:SF16; 1. DR Pfam; PF00611; FCH; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00055; FCH; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF103657; SSF103657; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR PROSITE; PS51741; F_BAR; 1. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE- KW ProRule:PRU01077, ECO:0000256|SAM:Coils}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}; KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}. FT DOMAIN 12..282 FT /note="F-BAR" FT /evidence="ECO:0000259|PROSITE:PS51741" FT DOMAIN 386..445 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT REGION 327..390 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 187..218 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 327..381 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 445 AA; 51356 MW; 53552263222290C5 CRC64; MSGAYDESAM SDETTDSFWE VGNYKRTVKR IEDGHRLCND MMSCIQERAK IEKAYSQQLT DWSKRWRQLV ERGPQYGTLE RAWLAVMTEA EKVSELHQEV KNNLLNEDLE KVKNWQKDAY HKQMMGGFKE TKEADEGFRK AQKPWAKKLK ELETAKKTYH MACKEEKIAS AREANSKGEA SVTTDQQKKL QEKVDKCKND VQKAKEKYEK SLDELNKCTP QYMENMEVVF DQCQQFEEKR LNFLREVLLD TKRHLNLTES QSYATVYREL ERTIVSASAQ EDLKWFSSVH GPGMHMNWPQ FEEFNPDLSH AISKKEKVKR NHDGVTLTQV THGAEHGTPQ TGDRGSVSSY EKNQQYSAEW SDDEQPPTAA QSASETNGGN PFEEDSKGVR VRALYDYEGQ EQDELTFKAG DELTKLEDED EQGWCKGRLD SGQLGLYPAN YVEPV //