ID B2DF58_9HIV1 Unreviewed; 193 AA. AC B2DF58; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 18-JUL-2018, entry version 38. DE RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341}; GN Name=vif {ECO:0000313|EMBL:BAG31098.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:BAG31098.1, ECO:0000313|Proteomes:UP000114870}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:BAG31098.1, ECO:0000313|Proteomes:UP000114870} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=#398 {ECO:0000313|EMBL:BAG31098.1}; RX PubMed=18620491; DOI=10.1089/aid.2008.0090; RA Ibe S., Shigemi U., Sawaki K., Fujisaki S., Hattori J., Yokomaku Y., RA Mamiya N., Hamaguchi M., Kaneda T.; RT "Analysis of near full-length genomic sequences of drug-resistant HIV- RT 1 spreading among therapy-naive individuals in Nagoya, Japan: amino RT acid mutations associated with viral replication activity."; RL AIDS Res. Hum. Retroviruses 24:1121-1125(2008). CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}; CC Peripheral membrane protein {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059686}; Cytoplasmic side CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}. CC Host cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059682}. CC Note=In the cytoplasm, seems to colocalize with intermediate CC filament vimentin. A fraction is associated with the cytoplasmic CC side of cellular membranes, presumably via the interaction with CC Pr55Gag precursor. {ECO:0000256|RuleBase:RU003341}. CC -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein CC family. {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059764}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB428560; BAG31098.1; -; Genomic_RNA. DR Proteomes; UP000114870; Genome. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0019058; P:viral life cycle; IEA:InterPro. DR HAMAP; MF_04081; HIV_VIF; 1. DR InterPro; IPR000475; Viral_infect. DR Pfam; PF00559; Vif; 1. DR PRINTS; PR00349; VIRIONINFFCT. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000114870}; KW Host cell membrane {ECO:0000256|SAAS:SAAS01059755}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS01059745}; KW Host membrane {ECO:0000256|SAAS:SAAS01059757}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01059733}; KW Membrane {ECO:0000256|SAAS:SAAS01059748}; KW Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01059744}; KW Virion {ECO:0000256|SAAS:SAAS01059762}. SQ SEQUENCE 193 AA; 22739 MW; 1D98B76B9DC8A93D CRC64; MENRWQVMIV WQVDRMRINI WKSLVKHHIH ISRKAKRWMY KHHYESTNPR ISSEVHIPLG EAELVITTYW GLHTGERDWQ LGHGVSIEWR KQRYNTQVDP DLADQLIHLY YFDCFSXSAI RNALLGHRVS PRCEYQAGHR KVGSLQYLAL TALITPTKKR KPPLPSVAKL TEDRWNKPQK TKGHRGSHTV NGH //