ID B2DF58_9HIV1 Unreviewed; 193 AA. AC B2DF58; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 19-JAN-2010, entry version 10. DE RecName: Full=Virion infectivity factor; GN Name=vif; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=#398; RX PubMed=18620491; DOI=10.1089/aid.2008.0090; RA Ibe S., Shigemi U., Sawaki K., Fujisaki S., Hattori J., Yokomaku Y., RA Mamiya N., Hamaguchi M., Kaneda T.; RT "Analysis of near full-length genomic sequences of drug-resistant HIV- RT 1 spreading among therapy-naive individuals in Nagoya, Japan: amino RT acid mutations associated with viral replication activity."; RL AIDS Res. Hum. Retroviruses 24:1121-1125(2008). CC -!- FUNCTION: Counteracts the innate antiviral activity of APOBEC3G. CC Forms a complex with host APOBEC3G thus preventing the entry of CC this lethally hypermutating enzyme into progeny virions. Functions CC as an adapter molecule, recruiting APOBEC3G to the ubiquitin- CC proteasome machinery. Targets APOBEC3G for degradation through the CC assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA CC and affects the stability of viral nucleoprotein core. May play a CC role in viral morphology (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB428560; BAG31098.1; -; Genomic_RNA. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW. DR GO; GO:0019058; P:viral infectious cycle; IEA:InterPro. DR InterPro; IPR000475; Viral_infect. DR Pfam; PF00559; Vif; 1. DR PRINTS; PR00349; VIRIONINFFCT. PE 3: Inferred from homology; KW AIDS; Host cell membrane; Host cytoplasm; Host membrane; KW Host-virus interaction; Membrane; Ubl conjugation pathway; Virion. SQ SEQUENCE 193 AA; 22739 MW; 1D98B76B9DC8A93D CRC64; MENRWQVMIV WQVDRMRINI WKSLVKHHIH ISRKAKRWMY KHHYESTNPR ISSEVHIPLG EAELVITTYW GLHTGERDWQ LGHGVSIEWR KQRYNTQVDP DLADQLIHLY YFDCFSXSAI RNALLGHRVS PRCEYQAGHR KVGSLQYLAL TALITPTKKR KPPLPSVAKL TEDRWNKPQK TKGHRGSHTV NGH //