ID B1NVE6_HUMAN Unreviewed; 260 AA. AC B1NVE6; DT 29-APR-2008, integrated into UniProtKB/TrEMBL. DT 29-APR-2008, sequence version 1. DT 01-OCT-2014, entry version 43. DE RecName: Full=Cytochrome c oxidase subunit 3 {ECO:0000256|RuleBase:RU003375}; GN Name=COX3 {ECO:0000313|EMBL:ABU47632.1}; OS Homo sapiens (Human). OG Mitochondrion {ECO:0000313|EMBL:ABU47632.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABU47632.1}; RN [1] {ECO:0000313|EMBL:ABU47632.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ZORO23 {ECO:0000313|EMBL:ABU47632.1}; RA Fagundes N.J.R., Kanitz R., Eckert R., Valls A.C.S., Bogo M.R., RA Salzano F.M., Glenn Smith D., Silva W.A.Jr., Zago M.A., RA Ribeiro-dos-Santos A.K., Santos A.E.B., Petzl-Erler M.L., RA Bonatto S.L.; RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABU47632.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ZORO23 {ECO:0000313|EMBL:ABU47632.1}; RX PubMed=18313026; DOI=10.1016/j.ajhg.2007.11.013; RA Fagundes N.J., Kanitz R., Eckert R., Valls A.C., Bogo M.R., RA Salzano F.M., Smith D.G., Silva W.A.Jr., Zago M.A., RA Ribeiro-dos-Santos A.K., Santos S.E., Petzl-Erler M.L., Bonatto S.L.; RT "Mitochondrial population genomics supports a single pre-Clovis origin RT with a coastal route for the peopling of the Americas."; RL Am. J. Hum. Genet. 82:583-592(2008). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. {ECO:0000256|RuleBase:RU003375}. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC {ECO:0000256|RuleBase:RU003375}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU095236; ABU47632.1; -; Genomic_DNA. DR ProteinModelPortal; B1NVE6; -. DR SMR; B1NVE6; 1-260. DR HOVERGEN; HBG016686; -. DR NextBio; 35467103; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR InterPro; IPR000298; Cyt_c_oxidase_su3_dom. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane; KW Mitochondrion {ECO:0000256|RuleBase:RU003375, KW ECO:0000313|EMBL:ABU47632.1}; KW Transmembrane {ECO:0000256|RuleBase:RU003375}. SQ SEQUENCE 260 AA; 29863 MW; 198F4FD48B71AF3E CRC64; MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTN TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE YFKSPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL FLYVSIYWWG //