ID B1AYC9_MOUSE Unreviewed; 670 AA. AC B1AYC9; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 14-DEC-2022, entry version 118. DE SubName: Full=Amyloid beta (A4) protein-binding, family B, member 1 interacting protein {ECO:0000313|EMBL:CAM24322.1}; GN Name=Apbb1ip {ECO:0000313|EMBL:CAM24322.1, GN ECO:0000313|MGI:MGI:1861354}; GN ORFNames=RP23-114M13.3-001 {ECO:0000313|EMBL:CAM24322.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CAM24322.1}; RN [1] {ECO:0000313|EMBL:CAM24322.1} RP NUCLEOTIDE SEQUENCE. RA Matthews N.; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PubMed:19144319} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [3] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0007829|PDB:6E31} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 27-437. RX PubMed=30733287; DOI=10.1073/pnas.1818880116; RA Chang Y.C., Su W., Cho E.A., Zhang H., Huang Q., Philips M.R., Wu J.; RT "Molecular basis for autoinhibition of RIAM regulated by FAK in integrin RT activation."; RL Proc. Natl. Acad. Sci. U.S.A. 116:3524-3529(2019). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL845427; CAM24322.1; -; Genomic_DNA. DR EMBL; BX649461; CAM24322.1; JOINED; Genomic_DNA. DR RefSeq; NP_062329.2; NM_019456.2. DR RefSeq; XP_006498249.1; XM_006498186.2. DR RefSeq; XP_011237441.1; XM_011239139.2. DR PDB; 6E31; X-ray; 2.40 A; A=27-437. DR PDBsum; 6E31; -. DR AlphaFoldDB; B1AYC9; -. DR SMR; B1AYC9; -. DR EPD; B1AYC9; -. DR PeptideAtlas; B1AYC9; -. DR Antibodypedia; 38122; 248 antibodies from 29 providers. DR DNASU; 54519; -. DR GeneID; 54519; -. DR KEGG; mmu:54519; -. DR AGR; MGI:1861354; -. DR CTD; 54518; -. DR MGI; MGI:1861354; Apbb1ip. DR VEuPathDB; HostDB:ENSMUSG00000026786; -. DR HOGENOM; CLU_023207_2_0_1; -. DR OMA; QENPGHP; -. DR OrthoDB; 786893at2759; -. DR PhylomeDB; B1AYC9; -. DR BioGRID-ORCS; 54519; 4 hits in 72 CRISPR screens. DR ChiTaRS; Apbb1ip; mouse. DR ExpressionAtlas; B1AYC9; baseline and differential. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd01259; PH_APBB1IP; 1. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR039664; GRB/APBB1IP. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR039665; PH_APBB1IP. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR000159; RA_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1. DR Pfam; PF00169; PH; 1. DR Pfam; PF00788; RA; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00314; RA; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. DR PROSITE; PS50200; RA; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:6E31}. FT DOMAIN 179..266 FT /note="Ras-associating" FT /evidence="ECO:0000259|PROSITE:PS50200" FT DOMAIN 313..422 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT REGION 449..653 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 449..477 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 554..618 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 670 AA; 74319 MW; 39EB28E468C479C8 CRC64; MGESNEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR EEFNYTVGFK DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESS QNQDRFALLR ASDGQGTASG GYGASAAAID VSHHEEALPP PPVEPMLDLL PPPPPPPPPE LLSKEEEEAK AKADKIKLAL EKLKEAKVKK LVVKVHMDDS STKSLMVDER QLARDVLDNL FEKTHCDCNV DWCLYEIYPE LQIERVFEDH ENVVEVLSDW TRDTENKVLF LEKEERYAVF KNPQNFYLDN KGKKENKETN EKMNAKNKEY LLEESFCGTS IIVPELEGAL YLKEDGKKSW KRRYFLLRAS GIYYVPKGKT KTSRDLACFI QFENVNIYYG IQCKMKYKAP TDHCFVLKHP QIQKESQYIK YLCCDDARTL SQWVMGIRIA KYGKTLYDNY QRAVARAGLA SRWTNLGTVG TPMPAQPSTV SSGLKTGTSQ PNGQMPQAIP SAGPPLQEAQ TQIETTKDEK QGLGNHSPGA TRENHRPKSS LPPPPPPVRR SSDTCGSPAL PSKVKGPGTC TFPHPPENFL PPPPPPPPEE DNSGLLPPPP PPPYLEEPPD FVPPPPPPAA VEDSALPPPP PPPPCLSQEI TKSSPLPPKK PLVPPKRQEN QGLPGAPGNS EQDFMSDLMK ALQKKRGNIP //