ID   B1AUY2_MOUSE            Unreviewed;       944 AA.
AC   B1AUY2;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   05-FEB-2025, entry version 125.
DE   SubName: Full=Rho GTPase activating protein 4 {ECO:0000313|Ensembl:ENSMUSP00000110046.2};
GN   Name=Arhgap4 {ECO:0000313|Ensembl:ENSMUSP00000110046.2,
GN   ECO:0000313|MGI:MGI:2159577};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000110046.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000110046.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110046.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000110046.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110046.2};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000110046.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110046.2};
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
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DR   RefSeq; NP_001155895.1; NM_001162423.1.
DR   AlphaFoldDB; B1AUY2; -.
DR   SMR; B1AUY2; -.
DR   jPOST; B1AUY2; -.
DR   ProteomicsDB; 312427; -.
DR   Antibodypedia; 360; 149 antibodies from 30 providers.
DR   DNASU; 171207; -.
DR   Ensembl; ENSMUST00000114404.8; ENSMUSP00000110046.2; ENSMUSG00000031389.18.
DR   GeneID; 171207; -.
DR   KEGG; mmu:171207; -.
DR   UCSC; uc012hkj.1; mouse.
DR   AGR; MGI:2159577; -.
DR   CTD; 393; -.
DR   MGI; MGI:2159577; Arhgap4.
DR   VEuPathDB; HostDB:ENSMUSG00000031389; -.
DR   GeneTree; ENSGT00950000182824; -.
DR   BioGRID-ORCS; 171207; 2 hits in 78 CRISPR screens.
DR   ChiTaRS; Arhgap4; mouse.
DR   Proteomes; UP000000589; Chromosome X.
DR   Bgee; ENSMUSG00000031389; Expressed in granulocyte and 120 other cell types or tissues.
DR   ExpressionAtlas; B1AUY2; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd07656; F-BAR_srGAP; 1.
DR   FunFam; 1.10.555.10:FF:000026; Rho GTPase activating protein 4; 1.
DR   FunFam; 2.30.30.40:FF:000404; Rho GTPase-activating protein 4; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR051627; SLIT-ROBO_RhoGAP.
DR   PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW   ProRule:PRU01077}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B1AUY2,
KW   ECO:0007829|ProteomicsDB:B1AUY2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          19..328
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          518..695
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          746..805
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          181..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          917..944
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          144..171
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        184..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..233
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..938
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  105226 MW;  1121493306B678B7 CRC64;
     MAAHGKLRRE RGLQPEYDAQ VKEMRWQLSE QLHCLELQGE LRRDLLQELA EFMRRRAEVE
     LEYSRGLDKL AERFTSRSGR LGGSSQEQQS FRKEPTLLSP LHCWAVLLEH TRQQSRESAA
     LSEVLAGPLA QRLSHISEDV GRIVKKSKDL VQQLQAELLE VVSELQTTKK MYHVYHSESM
     NAETKLREAE RQEEKRSGRS ALSTTTTTSA TTTTTTTTVE TGPHRKSSLK KGGRLVEKRQ
     AKYLEHKLKC TKARNEYLLS LASVNAAISN YYLHDILDLM DCCDTGFHLA LEQALRSYTA
     AESRTQTSQM QGLGSLEEAL EALDPPGDKA KVLEVHAMAF CPPLRFEYQP HEDDEVAEVL
     IEMELWDEIL PRAQNIQSRL DQKTIETEEV NKTLKATLKA LLEAVASEDG DILDSLQASP
     STESLKSTSS DPGTRQTGRR RNQQQETETF YITKLQEYLS GRSILSKLQA KHEKLQEAIQ
     QGNKEKQETS RTQCTERKFH KSHPPHPRFQ YNQRLFGGDL EKFIQSSGQP VPLVVESCIR
     FINLNGAQAR ISEIRDAFER GEDPLEKGCT VHDLDSVAGV LKLYFRSLEP PLFPLDMFNE
     LLASAELEVV GERVEPVSHL LFKLPRPVLV VLRYLFTFLN HLAQYSDENM MDSYNLAVCF
     GPTLLPVPAG QDPVALQGRV NQLVQTLILQ PARIFPPPAM LPGPIYEKCM APPSASCLGD
     GQLESLIGEP ELELKTGTTA QEDDQEGVLE AVACFAYTGR TAQELTFQRG DVLRLYARAS
     SDWWRGEHAG VQGLIPHKYI TLCEGDEKQM AGSGLQAMGE SVSHPEGFLT LEFANRLELG
     TPPEALGPSR HRRPCLVPTS PEGHVEMDKA VAQNMNSVFK ELLGKTAVRQ GHGLASTASP
     SLGTLTPLAC SSISKNKVFS RGPGAPISPS TSHPQGPDST RKPV
//