ID B1APE2_HUMAN Unreviewed; 231 AA. AC B1APE2; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 14-DEC-2022, entry version 112. DE RecName: Full=Transcription initiation factor IIB {ECO:0000256|ARBA:ARBA00013932}; DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184}; DE AltName: Full=General transcription factor TFIIB {ECO:0000256|ARBA:ARBA00031706}; DE Flags: Fragment; GN Name=GTF2B {ECO:0000313|Ensembl:ENSP00000402345.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402345.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000402345.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0007829|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [3] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] {ECO:0000313|Ensembl:ENSP00000402345.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00000780}; CC -!- SIMILARITY: Belongs to the TFIIB family. CC {ECO:0000256|ARBA:ARBA00010857}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL445991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; B1APE2; -. DR SMR; B1APE2; -. DR MaxQB; B1APE2; -. DR PeptideAtlas; B1APE2; -. DR ProteomicsDB; 3287; -. DR Antibodypedia; 19819; 454 antibodies from 35 providers. DR Ensembl; ENST00000418217.1; ENSP00000402345.1; ENSG00000137947.12. DR UCSC; uc057idc.1; human. DR HGNC; HGNC:4648; GTF2B. DR VEuPathDB; HostDB:ENSG00000137947; -. DR GeneTree; ENSGT00390000006671; -. DR HOGENOM; CLU_043736_1_1_1; -. DR ChiTaRS; GTF2B; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000137947; Expressed in oocyte and 202 other tissues. DR ExpressionAtlas; B1APE2; baseline and differential. DR GO; GO:0016604; C:nuclear body; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro. DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro. DR CDD; cd00043; CYCLIN; 1. DR InterPro; IPR013763; Cyclin-like. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR000812; TFIIB. DR InterPro; IPR023486; TFIIB_CS. DR InterPro; IPR013150; TFIIB_cyclin. DR InterPro; IPR013137; Znf_TFIIB. DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1. DR Pfam; PF00382; TFIIB; 1. DR PRINTS; PR00685; TIFACTORIIB. DR SMART; SM00385; CYCLIN; 1. DR SUPFAM; SSF47954; Cyclin-like; 1. DR PROSITE; PS00782; TFIIB; 1. DR PROSITE; PS51134; ZF_TFIIB; 1. PE 1: Evidence at protein level; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469}; KW Proteomics identification {ECO:0007829|EPD:B1APE2, KW ECO:0007829|MaxQB:B1APE2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}; KW Transferase {ECO:0000256|ARBA:ARBA00023315}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00469}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}. FT DOMAIN 11..42 FT /note="TFIIB-type" FT /evidence="ECO:0000259|PROSITE:PS51134" FT REGION 51..70 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 231 FT /evidence="ECO:0000313|Ensembl:ENSP00000402345.1" SQ SEQUENCE 231 AA; 25636 MW; 080BAE8E0C28DD97 CRC64; MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECDRV IDVGSEWRTF SNDKATKDPS RVGDSQNPLL SDGDLSTMIG KGTGAASFDE FGNSKYQNRR TMSSSDRAMM NAFKEITTMA DRINLPRNIV DRTNNLFKQV YEQKSLKGRA NDAIASACLY IACRQEGVPR TFKEICAVSR ISKKEIGRCF KLILKALETS VDLITTGDFM SRFCSNLCLP KQVQMAATHI A //