ID B1APE2_HUMAN Unreviewed; 231 AA. AC B1APE2; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 17-JUN-2020, entry version 100. DE SubName: Full=Transcription initiation factor IIB {ECO:0000313|Ensembl:ENSP00000402345}; DE Flags: Fragment; GN Name=GTF2B {ECO:0000313|Ensembl:ENSP00000402345}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402345, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000402345, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000402345} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [6] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL445991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; B1APE2; -. DR jPOST; B1APE2; -. DR MaxQB; B1APE2; -. DR PeptideAtlas; B1APE2; -. DR PRIDE; B1APE2; -. DR ProteomicsDB; 3287; -. DR Antibodypedia; 19819; 414 antibodies. DR Ensembl; ENST00000418217; ENSP00000402345; ENSG00000137947. DR UCSC; uc057idc.1; human. DR EuPathDB; HostDB:ENSG00000137947.11; -. DR HGNC; HGNC:4648; GTF2B. DR OpenTargets; ENSG00000137947; -. DR eggNOG; KOG1597; Eukaryota. DR eggNOG; COG1405; LUCA. DR GeneTree; ENSGT00390000006671; -. DR HOGENOM; CLU_043736_1_1_1; -. DR ChiTaRS; GTF2B; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000137947; Expressed in oocyte and 223 other tissues. DR ExpressionAtlas; B1APE2; baseline and differential. DR GO; GO:0016604; C:nuclear body; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro. DR CDD; cd00043; CYCLIN; 1. DR InterPro; IPR013763; Cyclin-like. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR000812; TFIIB. DR InterPro; IPR023486; TFIIB_CS. DR InterPro; IPR013150; TFIIB_cyclin. DR InterPro; IPR013137; Znf_TFIIB. DR PANTHER; PTHR11618; PTHR11618; 1. DR Pfam; PF00382; TFIIB; 1. DR PRINTS; PR00685; TIFACTORIIB. DR SMART; SM00385; CYCLIN; 1. DR SUPFAM; SSF47954; SSF47954; 1. DR PROSITE; PS00782; TFIIB; 1. DR PROSITE; PS51134; ZF_TFIIB; 1. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469}; KW Proteomics identification {ECO:0000213|EPD:B1APE2, KW ECO:0000213|MaxQB:B1APE2, ECO:0000213|PeptideAtlas:B1APE2, KW ECO:0000213|ProteomicsDB:B1APE2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00469}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}. FT DOMAIN 11..42 FT /note="TFIIB-type" FT /evidence="ECO:0000259|PROSITE:PS51134" FT ZN_FING 11..42 FT /note="TFIIB-type" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00469" FT REGION 51..70 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 231 FT /evidence="ECO:0000313|Ensembl:ENSP00000402345" SQ SEQUENCE 231 AA; 25636 MW; 080BAE8E0C28DD97 CRC64; MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECDRV IDVGSEWRTF SNDKATKDPS RVGDSQNPLL SDGDLSTMIG KGTGAASFDE FGNSKYQNRR TMSSSDRAMM NAFKEITTMA DRINLPRNIV DRTNNLFKQV YEQKSLKGRA NDAIASACLY IACRQEGVPR TFKEICAVSR ISKKEIGRCF KLILKALETS VDLITTGDFM SRFCSNLCLP KQVQMAATHI A //