ID B1AH42_HUMAN Unreviewed; 101 AA. AC B1AH42; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 29-MAY-2024, entry version 66. DE SubName: Full=Axin 1 {ECO:0000313|EMBL:CAQ09649.1}; DE Flags: Fragment; GN Name=AXIN1 {ECO:0000313|EMBL:CAQ09649.1}; GN ORFNames=LA16c-314G4.3-005 {ECO:0000313|EMBL:CAQ09649.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAQ09649.1}; RN [1] {ECO:0000313|EMBL:CAQ09649.1} RP NUCLEOTIDE SEQUENCE. RA Thomas K.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z69667; CAQ09649.1; -; Genomic_DNA. DR AlphaFoldDB; B1AH42; -. DR PeptideAtlas; B1AH42; -. DR ChiTaRS; AXIN1; human. DR GO; GO:0030877; C:beta-catenin destruction complex; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0008013; F:beta-catenin binding; IEA:TreeGrafter. DR GO; GO:0070411; F:I-SMAD binding; IEA:TreeGrafter. DR GO; GO:0042802; F:identical protein binding; IEA:TreeGrafter. DR GO; GO:0060090; F:molecular adaptor activity; IEA:TreeGrafter. DR GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:TreeGrafter. DR GO; GO:0048468; P:cell development; IEA:TreeGrafter. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro. DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:TreeGrafter. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 2.40.240.130; -; 1. DR InterPro; IPR043581; Axin-like. DR InterPro; IPR001158; DIX. DR InterPro; IPR038207; DIX_dom_sf. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR46102; AXIN; 1. DR PANTHER; PTHR46102:SF3; AXIN-1; 1. DR Pfam; PF00778; DIX; 1. DR SMART; SM00021; DAX; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50841; DIX; 1. PE 4: Predicted; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE- KW ProRule:PRU00069}. FT DOMAIN 31..101 FT /note="DIX" FT /evidence="ECO:0000259|PROSITE:PS50841" FT REGION 1..29 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAQ09649.1" SQ SEQUENCE 101 AA; 11378 MW; 34AEE46A8FFCFC1C CRC64; LEEEEKRASR APSKQRTRSQ RKVGGGSAQP CDSIVVAYYF CGEPIPYRTL VRGRAVTLGQ FKELLTKKGS YRPPSHLRCC LLTALLTSVL QILLQESERR V //