ID B1A803_9INFA Unreviewed; 468 AA. AC B1A803; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 13-NOV-2013, entry version 29. DE SubName: Full=Neuraminidase; GN Name=NA; OS Influenza A virus (A/duck/Eastern China/488/2003(H10N3)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=503313; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/Eastern China/488/2003; RA Qiu B.-F., Liu W.-J., Peng D.-X., Hu S.-L., Tang Y.-H., Liu X.-F.; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/Eastern China/488/2003; RX PubMed=18984006; DOI=10.1016/j.jviromet.2008.10.001; RA Qiu B.F., Liu W.J., Peng D.X., Hu S.L., Tang Y.H., Liu X.F.; RT "A reverse transcription-PCR for subtyping of the neuraminidase of RT avian influenza viruses."; RL J. Virol. Methods 155:193-198(2009). CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)- glycosidic linkages of terminal sialic acid residues CC in oligosaccharides, glycoproteins, glycolipids, colominic acid CC and synthetic substrates. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane. Host apical cell membrane; CC Single-pass type II membrane protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU429712; ACA04654.1; -; mRNA. DR CAZy; GH34; Glycoside Hydrolase Family 34. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR Gene3D; 2.120.10.10; -; 1. DR InterPro; IPR001860; Glyco_hydro_34. DR InterPro; IPR011040; Sialidases. DR Pfam; PF00064; Neur; 1. DR SUPFAM; SSF50939; SSF50939; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Glycosidase; Host cell membrane; Host membrane; KW Hydrolase; Membrane; Transmembrane; Transmembrane helix; Virion. SQ SEQUENCE 468 AA; 51631 MW; DA1216C047E89C94 CRC64; MNPNQKITTI GVVSTTLSTI ALLIGIGNLI FNTVIHEKIG DHQTVVYPTI TAPVVPNCSD TIITYNNTVV NNITTIITKA ETHFKSSLPL CPFRGFFPFH KDNAIRLGEN KNVIATREPY VSCDNDDCWS FALAQGALLG TKHSNGTIKD RTPYRSLIRF PIGTAPVLGN YKEICVAWSS SSCFDGKEWM HVCMTGNDND ASGQIMYAGK MTDSIKSWRK DILRTQESEC QCIDGTCVVA VTDGPAASSA DHRIYWIREG KVLKYENIPK TKIQHLEECS CYVDIDVYCI CRDNWKGSNR PWMRINNETI LETGYVCSKF HSDTPRPADP STVSCDSPSN VNGGPGVKGF GFKTGNDVWL GRTVSTSGRS GFEIIKVTEG WINSPNHAKS VTQTLVSNND WSGYSGSFIV ENNGCFQPCF YIELIRGRPN KNDDVSWTSN SIVTFCGLDN EPGSGNWPDG SNIGFMPK //