ID B0YJ53_HUMAN Unreviewed; 264 AA. AC B0YJ53; Q6FH49; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 28-JUN-2023, entry version 1. DE SubName: Full=Nicotinamide N-methyltransferase {ECO:0000313|EMBL:ACA06031.1}; DE SubName: Full=Nicotinamide N-methyltransferase, isoform CRA_a {ECO:0000313|EMBL:EAW67243.1}; GN Name=NNMT {ECO:0000313|EMBL:ACA06031.1}; GN ORFNames=hCG_39357 {ECO:0000313|EMBL:EAW67243.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACA06031.1}; RN [1] {ECO:0000313|EMBL:EAW67243.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:EAW67243.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ACA06031.1} RP NUCLEOTIDE SEQUENCE. RA Chin K.-J., Sharma M.L., Russell L.A., O'Neill K.R., Lovley D.R.; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0007829|PDB:7SOK} RP X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS). RA Iyamu I., Vilseck J.Z., Yadav R., Noinaj N., Huang R.; RT "Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with RT inhibitor II329."; RL Submitted (OCT-2021) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF445002; ACA06031.1; -; Genomic_DNA. DR EMBL; CH471065; EAW67243.1; -; Genomic_DNA. DR RefSeq; NP_006160.1; NM_006169.2. DR PDB; 7SOK; X-ray; 2.08 A; A/B/C/D=1-264. DR Antibodypedia; 18379; 543 antibodies from 34 providers. DR DNASU; 4837; -. DR GeneID; 4837; -. DR KEGG; hsa:4837; -. DR UCSC; uc001por.2; human. DR CTD; 4837; -. DR PharmGKB; PA251; -. DR VEuPathDB; HostDB:ENSG00000166741; -. DR HOGENOM; CLU_082526_1_1_1; -. DR OMA; FRCHRLK; -. DR OrthoDB; 5297821at2759; -. DR BioGRID-ORCS; 4837; 7 hits in 1162 CRISPR screens. DR ChiTaRS; NNMT; human. DR GenomeRNAi; 4837; -. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0008112; F:nicotinamide N-methyltransferase activity; IEA:Ensembl. DR GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR GO; GO:0006769; P:nicotinamide metabolic process; IEA:Ensembl. DR GO; GO:0045722; P:positive regulation of gluconeogenesis; IEA:Ensembl. DR GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl. DR GO; GO:0010243; P:response to organonitrogen compound; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl. DR CDD; cd02440; AdoMet_MTases; 1. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR InterPro; IPR025820; NNMT/PNMT/TEMT_CS. DR InterPro; IPR000940; NNMT_TEMT_trans. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR PANTHER; PTHR10867:SF32; NICOTINAMIDE N-METHYLTRANSFERASE; 1. DR PANTHER; PTHR10867; NNMT/PNMT/TEMT FAMILY MEMBER; 1. DR Pfam; PF01234; NNMT_PNMT_TEMT; 1. DR PIRSF; PIRSF000384; PNMTase; 1. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR PROSITE; PS01100; NNMT_PNMT_TEMT; 1. DR PROSITE; PS51681; SAM_MT_NNMT_PNMT_TEMT; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:7SOK}; KW Methyltransferase {ECO:0000313|EMBL:ACA06031.1}; KW Transferase {ECO:0000313|EMBL:ACA06031.1}. SQ SEQUENCE 264 AA; 29574 MW; 280B12748F4488AC CRC64; MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL //