ID B0R0C0_MOUSE Unreviewed; 353 AA. AC B0R0C0; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 22-FEB-2023, entry version 99. DE RecName: Full=Nociceptin receptor {ECO:0000256|ARBA:ARBA00021498}; DE AltName: Full=Kappa-type 3 opioid receptor {ECO:0000256|ARBA:ARBA00030257}; DE AltName: Full=Orphanin FQ receptor {ECO:0000256|ARBA:ARBA00030580}; GN Name=Oprl1 {ECO:0000313|Ensembl:ENSMUSP00000104394.2, GN ECO:0000313|MGI:MGI:97440}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000104394.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000104394.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000104394.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394.2}; RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC -!- FUNCTION: G-protein coupled opioid receptor that functions as receptor CC for the endogenous neuropeptide nociceptin. Ligand binding causes a CC conformation change that triggers signaling via guanine nucleotide- CC binding proteins (G proteins) and modulates the activity of down-stream CC effectors. Signaling via G proteins mediates inhibition of adenylate CC cyclase activity and calcium channel activity. Arrestins modulate CC signaling via G proteins and mediate the activation of alternative CC signaling pathways that lead to the activation of MAP kinases. Plays a CC role in modulating nociception and the perception of pain. Plays a role CC in the regulation of locomotor activity by the neuropeptide nociceptin. CC {ECO:0000256|ARBA:ARBA00025514}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. CC Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Vesicle CC {ECO:0000256|ARBA:ARBA00004373}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001305851.1; NM_001318922.1. DR AlphaFoldDB; B0R0C0; -. DR SMR; B0R0C0; -. DR SwissPalm; B0R0C0; -. DR Antibodypedia; 29994; 241 antibodies from 29 providers. DR DNASU; 18389; -. DR Ensembl; ENSMUST00000108763.8; ENSMUSP00000104394.2; ENSMUSG00000027584.18. DR GeneID; 18389; -. DR UCSC; uc008oni.2; mouse. DR AGR; MGI:97440; -. DR CTD; 4987; -. DR MGI; MGI:97440; Oprl1. DR VEuPathDB; HostDB:ENSMUSG00000027584; -. DR GeneTree; ENSGT00940000160661; -. DR OrthoDB; 5393360at2759; -. DR BioGRID-ORCS; 18389; 2 hits in 77 CRISPR screens. DR ChiTaRS; Oprl1; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000027584; Expressed in neural tube lateral wall and 126 other tissues. DR ExpressionAtlas; B0R0C0; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0001626; F:nociceptin receptor activity; IEA:InterPro. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR001418; Opioid_rcpt. DR InterPro; IPR001420; X_opioid_rcpt. DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1. DR PANTHER; PTHR24229:SF11; NOCICEPTIN RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PRINTS; PR00547; XOPIOIDR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Behavior {ECO:0000256|ARBA:ARBA00022610}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 71..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 96..115 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 155..174 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 194..222 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 243..262 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 282..305 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 51..302 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 353 AA; 38542 MW; A925B71F0F69D5CF CRC64; MRPYPITCSS MLATVPSCPL DSRSPSWGST WLCASGGSWG TASSCMSSSA GRALRGTGDS RHTKMKTATN IYIFNLALAD TLVLLTLPFQ GTDILLGFWP FGNALCKTVI AIDYYNMFTS TFTLTAMSVD RYVAICHPIR ALDVRTSSKA QAVNVAIWAL ASVVGVPVAI MGSAQVEDEE IECLVEIPAP QDYWGPVFAI CIFLFSFIIP VLIISVCYSL MIRRLRGVRL LSGSREKDRN LRRITRLVLV VVAVFVGCWT PVQVFVLVQG LGVQPGSETA VAILRFCTAL GYVNSCLNPI LYAFLDENFK ACFRKFCCAS ALHREMQVSD RVRSIAKDVG LGCKTSETVP RPA //