ID B0R0C0_MOUSE Unreviewed; 353 AA. AC B0R0C0; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 05-JUL-2017, entry version 71. DE SubName: Full=Nociceptin receptor {ECO:0000313|Ensembl:ENSMUSP00000104394}; DE SubName: Full=Opioid receptor-like 1, isoform CRA_i {ECO:0000313|EMBL:EDL07458.1}; GN Name=Oprl1 {ECO:0000313|EMBL:EDL07458.1, GN ECO:0000313|Ensembl:ENSMUSP00000104394, ECO:0000313|MGI:MGI:97440}; GN ORFNames=mCG_21542 {ECO:0000313|EMBL:EDL07458.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000104394, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL07458.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL07458.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDL07458.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL07458.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000104394, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000104394} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL845173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH466626; EDL07458.1; -; Genomic_DNA. DR RefSeq; NP_001305851.1; NM_001318922.1. DR UniGene; Mm.285075; -. DR Ensembl; ENSMUST00000108763; ENSMUSP00000104394; ENSMUSG00000027584. DR GeneID; 18389; -. DR UCSC; uc008oni.2; mouse. DR CTD; 4987; -. DR MGI; MGI:97440; Oprl1. DR eggNOG; KOG3656; Eukaryota. DR eggNOG; ENOG410XRW9; LUCA. DR GeneTree; ENSGT00760000118797; -. DR HOGENOM; HOG000230486; -. DR HOVERGEN; HBG106919; -. DR ChiTaRS; Oprl1; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000027584; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0001626; F:nociceptin receptor activity; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR001418; Opioid_rcpt. DR InterPro; IPR001420; X_opioid_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PRINTS; PR00547; XOPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:EDL07458.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 71 90 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 96 115 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 155 174 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 194 222 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 243 262 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 282 305 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 51 302 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 353 AA; 38542 MW; A925B71F0F69D5CF CRC64; MRPYPITCSS MLATVPSCPL DSRSPSWGST WLCASGGSWG TASSCMSSSA GRALRGTGDS RHTKMKTATN IYIFNLALAD TLVLLTLPFQ GTDILLGFWP FGNALCKTVI AIDYYNMFTS TFTLTAMSVD RYVAICHPIR ALDVRTSSKA QAVNVAIWAL ASVVGVPVAI MGSAQVEDEE IECLVEIPAP QDYWGPVFAI CIFLFSFIIP VLIISVCYSL MIRRLRGVRL LSGSREKDRN LRRITRLVLV VVAVFVGCWT PVQVFVLVQG LGVQPGSETA VAILRFCTAL GYVNSCLNPI LYAFLDENFK ACFRKFCCAS ALHREMQVSD RVRSIAKDVG LGCKTSETVP RPA //