ID B0R0C0_MOUSE Unreviewed; 353 AA. AC B0R0C0; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 29-MAY-2024, entry version 106. DE RecName: Full=Nociceptin receptor {ECO:0000256|ARBA:ARBA00021498}; DE AltName: Full=Kappa-type 3 opioid receptor {ECO:0000256|ARBA:ARBA00030257}; DE AltName: Full=Orphanin FQ receptor {ECO:0000256|ARBA:ARBA00030580}; GN Name=Oprl1 {ECO:0000313|Ensembl:ENSMUSP00000104394.2, GN ECO:0000313|MGI:MGI:97440}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000104394.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000104394.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000104394.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104394.2}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- FUNCTION: G-protein coupled opioid receptor that functions as a CC receptor for the endogenous neuropeptide nociceptin. Ligand binding CC causes a conformation change that triggers signaling via guanine CC nucleotide-binding proteins (G proteins) and modulates the activity of CC down-stream effectors. Signaling via G proteins mediates inhibition of CC adenylate cyclase activity and calcium channel activity. Arrestins CC modulate signaling via G proteins and mediate the activation of CC alternative signaling pathways that lead to the activation of MAP CC kinases. Plays a role in modulating nociception and the perception of CC pain. Plays a role in the regulation of locomotor activity by the CC neuropeptide nociceptin. {ECO:0000256|ARBA:ARBA00043899}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001305851.1; NM_001318922.1. DR AlphaFoldDB; B0R0C0; -. DR SMR; B0R0C0; -. DR SwissPalm; B0R0C0; -. DR Antibodypedia; 29994; 262 antibodies from 29 providers. DR DNASU; 18389; -. DR Ensembl; ENSMUST00000108763.8; ENSMUSP00000104394.2; ENSMUSG00000027584.18. DR GeneID; 18389; -. DR UCSC; uc008oni.2; mouse. DR AGR; MGI:97440; -. DR CTD; 4987; -. DR MGI; MGI:97440; Oprl1. DR VEuPathDB; HostDB:ENSMUSG00000027584; -. DR GeneTree; ENSGT00940000160661; -. DR OrthoDB; 5393360at2759; -. DR BioGRID-ORCS; 18389; 2 hits in 77 CRISPR screens. DR ChiTaRS; Oprl1; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000027584; Expressed in neural tube lateral wall and 128 other cell types or tissues. DR ExpressionAtlas; B0R0C0; baseline and differential. DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042923; F:neuropeptide binding; IEA:TreeGrafter. DR GO; GO:0001626; F:nociceptin receptor activity; IEA:InterPro. DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:TreeGrafter. DR GO; GO:0019233; P:sensory perception of pain; IEA:TreeGrafter. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR001418; Opioid_rcpt. DR InterPro; IPR001420; X_opioid_rcpt. DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1. DR PANTHER; PTHR24229:SF11; NOCICEPTIN RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PRINTS; PR00547; XOPIOIDR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Behavior {ECO:0000256|ARBA:ARBA00022610}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 71..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 96..115 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 155..174 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 194..222 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 243..262 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 282..305 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 51..302 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 353 AA; 38542 MW; A925B71F0F69D5CF CRC64; MRPYPITCSS MLATVPSCPL DSRSPSWGST WLCASGGSWG TASSCMSSSA GRALRGTGDS RHTKMKTATN IYIFNLALAD TLVLLTLPFQ GTDILLGFWP FGNALCKTVI AIDYYNMFTS TFTLTAMSVD RYVAICHPIR ALDVRTSSKA QAVNVAIWAL ASVVGVPVAI MGSAQVEDEE IECLVEIPAP QDYWGPVFAI CIFLFSFIIP VLIISVCYSL MIRRLRGVRL LSGSREKDRN LRRITRLVLV VVAVFVGCWT PVQVFVLVQG LGVQPGSETA VAILRFCTAL GYVNSCLNPI LYAFLDENFK ACFRKFCCAS ALHREMQVSD RVRSIAKDVG LGCKTSETVP RPA //