ID   B0K365_THEPX            Unreviewed;       274 AA.
AC   B0K365;
DT   18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT   18-MAR-2008, sequence version 1.
DT   16-DEC-2008, entry version 10.
DE   SubName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase;
DE            EC=2.1.2.11;
GN   OrderedLocusNames=Teth514_0427;
OS   Thermoanaerobacter sp. (strain X514).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacter.
OX   NCBI_TaxID=399726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E.,
RA   Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J.,
RA   Richardson P.;
RT   "Complete sequence of Thermoanaerobacter sp. X514.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible reaction in which hydroxymethyl
CC       group from 5,10-methylenetetrahydrofolate is tranferred onto
CC       alpha-ketoisovalerate to form ketopantoate.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + 3-methyl-2-
CC       oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit.
CC   -!- SUBUNIT: Homodecamer; pentamer of dimers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000923; ABY91737.1; -; Genomic_DNA.
DR   RefSeq; YP_001662073.1; -.
DR   GeneID; 5877019; -.
DR   GenomeReviews; CP000923_GR; Teth514_0427.
DR   KEGG; tex:Teth514_0427; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003864; F:3-methyl-2-oxobutanoate hydroxymethyltransf...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003700; Pantoate_hydroxy_MeTrfase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase_cat.
DR   Gene3D; G3DSA:3.20.20.60; Pyrv/PenolPyrv_Kinase_cat; 1.
DR   PANTHER; PTHR20881; Pantoate_transf; 1.
DR   Pfam; PF02548; Pantoate_transf; 1.
DR   PIRSF; PIRSF000388; Pantoate_hydroxy_MeTrfase; 1.
DR   TIGRFAMs; TIGR00222; panB; 1.
PE   4: Predicted;
KW   Complete proteome; Cytoplasm; Magnesium; Metal-binding;
KW   Methyltransferase; Pantothenate biosynthesis; Transferase.
SQ   SEQUENCE   274 AA;  29988 MW;  758752D0F4E653B8 CRC64;
     MEEKVSTLTL RKFKKEGRKI TALTAYDFPT AKILDNCGID MILVGDSLGM VVLGYESTIP
     VTMEDMIHHT KAVSRAVNRA FIVADMPFMS YHISKEQAMT NAARLIAEGG AHAVKLEGGE
     EIASIVKAIV DAGIPVVGHL GLTPQSVHQL GGYKVQGKEK EQAKKIFNDA KVLEQAGICA
     LVLESIPMEL AKNITENISV PTIGIGAGPY CDGQILVTHD MLGITQGHRP KFVKQYADIE
     KIMIDGINAY IKEVQQVLFP DEEHSFTLEK RENK
//