ID   RISB_RENSM              Reviewed;         159 AA.
AC   A9WR65;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   02-SEP-2008, entry version 9.
DE   RecName: Full=6,7-dimethyl-8-ribityllumazine synthase;
DE            Short=DMRL synthase;
DE            Short=Lumazine synthase;
DE            EC=2.5.1.9;
DE   AltName: Full=Riboflavin synthase beta chain;
GN   Name=ribH; OrderedLocusNames=RSal33209_2344;
OS   Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / IFO
OS   15589).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Renibacterium.
OX   NCBI_TaxID=288705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wiens G.D., Rockey D.R., Wu Z., Gillett W., Hayden H., Crane S.,
RA   Chen D.S., Capri G.R., Burnett J.R., Ponnerassery S., Schipma M.J.,
RA   Burd H., Bhattacharyya A., Kaul R., Rhodes L.D., Strom M.S.;
RT   "The genome sequence of Renibacterium salmoninarum ATCC 33209 suggests
RT   reductive genome evolution from environmental Arthrobacter.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Riboflavin synthase is a bifunctional enzyme complex
CC       catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-
CC       ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-
CC       butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit
CC       catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-
CC       2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-
CC       phosphate yielding 6,7-dimethyl-8-lumazine (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine =
CC       riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 6,7-
CC       dimethyl-8-(1-D-ribityl)lumazine and riboflavin from 4-(1-D-
CC       ribitylamino)-5-amino-2,6-dihydroxypyrimidine: step 1/1.
CC   -!- SIMILARITY: Belongs to the DMRL synthase family.
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DR   EMBL; CP000910; ABY24074.1; -; Genomic_DNA.
DR   RefSeq; YP_001625488.1; -.
DR   GeneID; 5824327; -.
DR   GenomeReviews; CP000910_GR; RSal33209_2344.
DR   KEGG; rsa:RSal33209_2344; -.
DR   GO; GO:0004746; F:riboflavin synthase activity; IEA:HAMAP.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00178; -; 1.
DR   InterPro; IPR002180; DMRL_synthase.
DR   Gene3D; G3DSA:3.40.50.960; DMRL_synthase; 1.
DR   PANTHER; PTHR21058; DMRL_synthase; 1.
DR   ProDom; PD003664; DMRL_synthase; 1.
DR   TIGRFAMs; TIGR00114; lumazine-synth; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Riboflavin biosynthesis; Transferase.
FT   CHAIN         1    159       6,7-dimethyl-8-ribityllumazine synthase.
FT                                /FTId=PRO_1000077245.
SQ   SEQUENCE   159 AA;  16339 MW;  B9AE0B824EAFEDD3 CRC64;
     MSGAGAPVSP QLNAKGLELV IIAASWHEKV MNGLLDGALR AARDAGIEEP RIVRVPGSFE
     LPVAAARLAP DYDAVVALGV VIRGGTPHFE YVCQAATSGL TEVSVRTGVP VGFGLLTCDN
     DQQALDRAGL PAAPGFAGSK EDKGYEATSA ALETALTLR
//