ID A9UI05_9HIV1 Unreviewed; 343 AA. AC A9UI05; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 29-SEP-2021, entry version 73. DE RecName: Full=Protease {ECO:0000256|ARBA:ARBA00016591}; DE AltName: Full=Retropepsin {ECO:0000256|ARBA:ARBA00019041}; DE Flags: Fragment; GN Name=pol {ECO:0000313|EMBL:ABX84078.1}; OS Human immunodeficiency virus 1. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABX84078.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ABX84078.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NV38 {ECO:0000313|EMBL:ABX84078.1}; RX PubMed=18572440; DOI=10.1089/aid.2008.0051; RA McConnell M.J., Docobo-Perez F., Mata R.C., Fernandez-Cuenca F., RA Viciana P., Lopez-Cortes L.F., Trastoy M., Pachon J., Perez-Romero P.; RT "Molecular epidemiology of HIV type 1 in newly diagnosed patients in RT southern Spain."; RL AIDS Res. Hum. Retroviruses 24:881-887(2008). CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family. CC {ECO:0000256|RuleBase:RU004064}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU288123; ABX84078.1; -; Genomic_DNA. DR MEROPS; A02.001; -. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW. DR CDD; cd05482; HIV_retropepsin_like; 1. DR Gene3D; 2.40.70.10; -; 1. DR Gene3D; 3.30.70.270; -; 1. DR InterPro; IPR001969; Aspartic_peptidase_AS. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR001995; Peptidase_A2_cat. DR InterPro; IPR021109; Peptidase_aspartic_dom_sf. DR InterPro; IPR034170; Retropepsin-like_cat_dom. DR InterPro; IPR018061; Retropepsins. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR000477; RT_dom. DR Pfam; PF00077; RVP; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF50630; SSF50630; 1. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS50175; ASP_PROT_RETROV; 1. DR PROSITE; PS00141; ASP_PROTEASE; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750, KW ECO:0000256|RuleBase:RU004064}; KW DNA integration {ECO:0000256|ARBA:ARBA00023195}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004064}; KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195}. FT DOMAIN 17..86 FT /note="Peptidase A2" FT /evidence="ECO:0000259|PROSITE:PS50175" FT DOMAIN 140..330 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABX84078.1" FT NON_TER 343 FT /evidence="ECO:0000313|EMBL:ABX84078.1" SQ SEQUENCE 343 AA; 39213 MW; C0E064714E6E3565 CRC64; TLWQRPLVTI KIGGQLKEAL LDTGADDTVL EEMDLPGRWK PKMIGGIGGF IKVRQYDQIP IEICGHKAIG TVLIGPTPVN IIGRNLLTQL GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXCTEMEKE GKITKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA YFSVPLDKEF RKYTAFTIPS INNETPGIRY QYNVLPQGWK GSPAIFQSSM TKILEPFRKQ NPEIVIYQYM DDLYVGSDLE IGQHRXKIEE SRHHLLRWGF TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI VLP //