ID A9UI05_9HIV1 Unreviewed; 343 AA. AC A9UI05; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 09-JAN-2013, entry version 29. DE SubName: Full=Pol protein; DE Flags: Fragment; GN Name=pol; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NV38; RA Perez-Romero P., McConnell M.J., Docobo-Perez F., Mata R.C., RA Trastoy M., Lopez-Cortes L.F., Viciana P., Fernandez-Cuenca F., RA Pachon J.; RT "Molecular Epidemiology of HIV-1 in Newly Diagnosed Patients in RT Southern Spain."; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = CC diphosphate + DNA(n+1). CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family. CC -!- SIMILARITY: Contains 1 peptidase A2 domain. CC -!- SIMILARITY: Contains 1 reverse transcriptase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU288123; ABX84078.1; -; Genomic_DNA. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro. DR Gene3D; 2.40.70.10; Pept_Aspartc_cat; 1. DR InterPro; IPR018061; Pept_A2A_retrovirus_sg. DR InterPro; IPR001995; Peptidase_A2_cat. DR InterPro; IPR021109; Peptidase_aspartic. DR InterPro; IPR001969; Peptidase_aspartic_AS. DR InterPro; IPR009007; Peptidase_aspartic_catalytic. DR InterPro; IPR000477; RVT. DR Pfam; PF00077; RVP; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF50630; Pept_Aspartic; 1. DR PROSITE; PS50175; ASP_PROT_RETROV; 1. DR PROSITE; PS00141; ASP_PROTEASE; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Aspartyl protease; Hydrolase; Multifunctional enzyme; KW Nucleotidyltransferase; Protease; RNA-directed DNA polymerase; KW Transferase. FT NON_TER 1 1 FT NON_TER 343 343 SQ SEQUENCE 343 AA; 39213 MW; C0E064714E6E3565 CRC64; TLWQRPLVTI KIGGQLKEAL LDTGADDTVL EEMDLPGRWK PKMIGGIGGF IKVRQYDQIP IEICGHKAIG TVLIGPTPVN IIGRNLLTQL GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXCTEMEKE GKITKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA YFSVPLDKEF RKYTAFTIPS INNETPGIRY QYNVLPQGWK GSPAIFQSSM TKILEPFRKQ NPEIVIYQYM DDLYVGSDLE IGQHRXKIEE SRHHLLRWGF TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI VLP //