ID KIF22_DANRE Reviewed; 634 AA. AC A8WFU8; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 15-JAN-2008, sequence version 1. DT 07-APR-2021, entry version 72. DE RecName: Full=Kinesin-like protein KIF22; GN Name=kif22; ORFNames=zgc:171724; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Kinesin family member that is involved in spindle formation CC and the movements of chromosomes during mitosis and meiosis. Binds to CC microtubules and to DNA. {ECO:0000250|UniProtKB:Q9I869}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9I869}. CC Cytoplasm, cytoskeleton {ECO:0000305}. CC -!- PTM: Ubiquitinated, leading to its subsequent proteasomal degradation. CC {ECO:0000250|UniProtKB:Q9I869}. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC154464; AAI54465.1; -; mRNA. DR RefSeq; NP_001107063.1; NM_001113591.1. DR STRING; 7955.ENSDARP00000103034; -. DR PaxDb; A8WFU8; -. DR PeptideAtlas; A8WFU8; -. DR GeneID; 561788; -. DR KEGG; dre:561788; -. DR CTD; 3835; -. DR ZFIN; ZDB-GENE-080204-34; kif22. DR eggNOG; KOG0242; Eukaryota. DR InParanoid; A8WFU8; -. DR OrthoDB; 398790at2759; -. DR Reactome; R-DRE-2132295; MHC class II antigen presentation. DR Reactome; R-DRE-6811434; COPI-dependent Golgi-to-ER retrograde traffic. DR Reactome; R-DRE-983189; Kinesins. DR PRO; PR:A8WFU8; -. DR Proteomes; UP000000437; Unplaced. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central. DR GO; GO:0005874; C:microtubule; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:1990939; F:ATP-dependent microtubule motor activity; IEA:InterPro. DR GO; GO:0016887; F:ATPase activity; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central. DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central. DR GO; GO:0007409; P:axonogenesis; IMP:ZFIN. DR GO; GO:0007420; P:brain development; IMP:ZFIN. DR GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IMP:ZFIN. DR GO; GO:0048592; P:eye morphogenesis; IMP:ZFIN. DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central. DR GO; GO:0001756; P:somitogenesis; IMP:ZFIN. DR GO; GO:0001966; P:thigmotaxis; IMP:ZFIN. DR Gene3D; 3.40.850.10; -; 1. DR InterPro; IPR026986; KIF22. DR InterPro; IPR027640; Kinesin-like_fam. DR InterPro; IPR019821; Kinesin_motor_CS. DR InterPro; IPR001752; Kinesin_motor_dom. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR010994; RuvA_2-like. DR PANTHER; PTHR24115; PTHR24115; 1. DR PANTHER; PTHR24115:SF801; PTHR24115:SF801; 1. DR Pfam; PF00225; Kinesin; 1. DR PRINTS; PR00380; KINESINHEAVY. DR SMART; SM00129; KISc; 1. DR SUPFAM; SSF47781; SSF47781; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00411; KINESIN_MOTOR_1; 1. DR PROSITE; PS50067; KINESIN_MOTOR_2; 1. PE 2: Evidence at transcript level; KW ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; DNA-binding; KW Microtubule; Motor protein; Nucleotide-binding; Nucleus; KW Reference proteome; Ubl conjugation. FT CHAIN 1..634 FT /note="Kinesin-like protein KIF22" FT /id="PRO_0000347237" FT DOMAIN 19..345 FT /note="Kinesin motor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283" FT NP_BIND 103..110 FT /note="ATP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283" FT COILED 421..471 FT /evidence="ECO:0000255" SQ SEQUENCE 634 AA; 70593 MW; B9FF21ABFBBF4684 CRC64; MAQRVAVNDG AAGSKRTSRV RVAVRLRPYM DKQDEKSEGS CVRGLGPQKL EIINWRNATE TLQYQFDVFH GEETTQQEVF LTSVKPILPH ILNGQNASVF AYGPTGAGKT HTMLGSQEQP GVIPRAVKEV FNLVGAQKKE QDGWEYSIGM SYLEIYNEKV LDLLSPGSQD LPIREDKDRN ILIPGLTHTP LSSFADFDTH FIPASLNRTT ASTKLNQRSS RSHAILLIKV VKSQRGPPHR QQTGKLYLVD LAGSEDNRRT GNQGIRLKES GAINLSLFTL SKVVDALNTG AGGRVPYRDS KLTRLLQDSL GGSAHSVMIT NIAPEYKYYF DTFSALNFAA KSKQIVNRPF VRETVLAPTI APGKRTREEQ EAGGSGEPQN KRSKEGKKAE HSPSPPLHPQ SSPDSSVLDR LLALEKMMMG SAERERLNLL KTVAQSRKEI QMLKEKQKEL EDKANMFNKQ KETTEKESKD ALLFKTDLPP LHRKQSTAAK PRKQQAVVTP LQVSQVQPLQ QCAVVCKPSQ TLVKKKRVQT EVCDGKENIG VDLPPVEDVN WESRLDPALL EQSRKKILQT LNSGSLKELK SLQQIGDKKA KLIMGWREIN GDFTQVEDLK KIEGVTVKRF SSFIKANILS SMGK //