ID A8VGH4_HEMSA Unreviewed; 175 AA. AC A8VGH4; DT 15-JAN-2008, integrated into UniProtKB/TrEMBL. DT 15-JAN-2008, sequence version 1. DT 25-NOV-2008, entry version 7. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Hemigrapsus sanguineus (Crab). OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura; OC Eubrachyura; Grapsoidea; Varunidae; Hemigrapsus. OX NCBI_TaxID=40176; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hs24; RA McCafferty S.S., Madeira M., Parks S.; RT "Genetic variation of the CO1 gene in Hemigrapsus sanguineus among RT source populations along the east coast of the United States."; RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU169909; ABW76006.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0005746; C:mitochondrial respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_oxidase_su1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Membrane; Mitochondrion; KW Oxidoreductase; Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 175 175 SQ SEQUENCE 175 AA; 18751 MW; 5183693E725E1B4C CRC64; LSQPGSLIGN DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMLGAP DMAFPRMNNM SFWLLPPSLS LLLTSSMVES GVGTGWTVYP PLAAAIAHAG ASVDLGIFSL HLAGVSSILG AVNFMTTVIN MRSYGMTMDQ MPLFVWAVFI TAILLLLSLP VLAGAITMLL TDRNL //