ID   SMI10_BOVIN             Reviewed;         133 AA.
AC   A8SMG2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   27-NOV-2024, entry version 63.
DE   RecName: Full=Sperm-associated microtubule inner protein 10;
DE   AltName: Full=Testis-expressed protein 43;
GN   Name=SPMIP10; Synonyms=C5orf48, TEX43;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:8OTZ}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS), FUNCTION, SUBUNIT,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=37327785; DOI=10.1016/j.cell.2023.05.026;
RA   Leung M.R., Zeng J., Wang X., Roelofs M.C., Huang W., Zenezini Chiozzi R.,
RA   Hevler J.F., Heck A.J.R., Dutcher S.K., Brown A., Zhang R.,
RA   Zeev-Ben-Mordehai T.;
RT   "Structural specializations of the sperm tail.";
RL   Cell 186:2880-2896(2023).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in flagellum axoneme, which is required for
CC       flagellum beating (PubMed:37327785). May serve to reinforce and thus
CC       stabilize the microtubule structure in the sperm flagella
CC       (PubMed:37327785). Involved in the regulation of sperm motility (By
CC       similarity). {ECO:0000250|UniProtKB:Q9D9I1,
CC       ECO:0000269|PubMed:37327785}.
CC   -!- SUBUNIT: Microtubule inner protein component of sperm flagellar doublet
CC       microtubules. {ECO:0000269|PubMed:37327785}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000269|PubMed:37327785}. Note=Localizes at the ribbon and inner
CC       junction (IJ) between A- and B-tubules of the DMTs.
CC       {ECO:0000269|PubMed:37327785}.
CC   -!- TISSUE SPECIFICITY: Expressed in sperm. {ECO:0000269|PubMed:37327785}.
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DR   EMBL; EH372678; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC126782; AAI26783.1; -; mRNA.
DR   RefSeq; NP_001181999.1; NM_001195070.1.
DR   PDB; 8OTZ; EM; 3.60 A; Di/Dj/Dk/Dl=1-133.
DR   PDBsum; 8OTZ; -.
DR   AlphaFoldDB; A8SMG2; -.
DR   EMDB; EMD-17187; -.
DR   SMR; A8SMG2; -.
DR   STRING; 9913.ENSBTAP00000056234; -.
DR   PaxDb; 9913-ENSBTAP00000056234; -.
DR   Ensembl; ENSBTAT00000064793.2; ENSBTAP00000056234.1; ENSBTAG00000046718.3.
DR   GeneID; 100126817; -.
DR   KEGG; bta:100126817; -.
DR   CTD; 100126817; -.
DR   VEuPathDB; HostDB:ENSBTAG00000046718; -.
DR   VGNC; VGNC:35771; SPMIP10.
DR   eggNOG; ENOG502S426; Eukaryota.
DR   GeneTree; ENSGT00390000006935; -.
DR   HOGENOM; CLU_131594_1_0_1; -.
DR   InParanoid; A8SMG2; -.
DR   OMA; PKITNNC; -.
DR   OrthoDB; 5317944at2759; -.
DR   TreeFam; TF339864; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000046718; Expressed in semen and 10 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR   InterPro; IPR027965; SPMIP10.
DR   PANTHER; PTHR35247; TESTIS-EXPRESSED PROTEIN 43; 1.
DR   PANTHER; PTHR35247:SF1; TESTIS-EXPRESSED PROTEIN 43; 1.
DR   Pfam; PF14983; SPMIP10-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..133
FT                   /note="Sperm-associated microtubule inner protein 10"
FT                   /id="PRO_0000321823"
SQ   SEQUENCE   133 AA;  15181 MW;  38EA56A5D7F8D9DC CRC64;
     MASGKDTCPI LPKLTNNCSD ENSDKLANKC EIHLPRFSLK QGMIPRHYVM PWKQNMKFRN
     VNLKHAEACG IHAGPLEDSL FLDHSERLCH GEDRKVVLKK GPPEIKIADM PLHSPLSRYQ
     STVISHGFRR RLI
//