ID SMI10_BOVIN Reviewed; 133 AA. AC A8SMG2; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 26-FEB-2008, sequence version 2. DT 02-OCT-2024, entry version 62. DE RecName: Full=Sperm-associated microtubule inner protein 10; DE AltName: Full=Testis-expressed protein 43; GN Name=SPMIP10; Synonyms=C5orf48, TEX43; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Crossbred X Angus; TISSUE=Liver; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007744|PDB:8OTZ} RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS), FUNCTION, SUBUNIT, RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=37327785; DOI=10.1016/j.cell.2023.05.026; RA Leung M.R., Zeng J., Wang X., Roelofs M.C., Huang W., Zenezini Chiozzi R., RA Hevler J.F., Heck A.J.R., Dutcher S.K., Brown A., Zhang R., RA Zeev-Ben-Mordehai T.; RT "Structural specializations of the sperm tail."; RL Cell 186:2880-2896(2023). CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated CC doublet microtubules (DMTs) in flagellum axoneme, which is required for CC flagellum beating (PubMed:37327785). May serve to reinforce and thus CC stabilize the microtubule structure in the sperm flagella CC (PubMed:37327785). Involved in the regulation of sperm motility (By CC similarity). {ECO:0000250|UniProtKB:Q9D9I1, CC ECO:0000269|PubMed:37327785}. CC -!- SUBUNIT: Microtubule inner protein component of sperm flagellar doublet CC microtubules. {ECO:0000269|PubMed:37327785}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme CC {ECO:0000269|PubMed:37327785}. Note=Localizes at the ribbon and inner CC junction (IJ) between A- and B-tubules of the DMTs. CC {ECO:0000269|PubMed:37327785}. CC -!- TISSUE SPECIFICITY: Expressed in sperm. {ECO:0000269|PubMed:37327785}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EH372678; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC126782; AAI26783.1; -; mRNA. DR RefSeq; NP_001181999.1; NM_001195070.1. DR PDB; 8OTZ; EM; 3.60 A; Di/Dj/Dk/Dl=1-133. DR PDBsum; 8OTZ; -. DR AlphaFoldDB; A8SMG2; -. DR EMDB; EMD-17187; -. DR SMR; A8SMG2; -. DR STRING; 9913.ENSBTAP00000056234; -. DR PaxDb; 9913-ENSBTAP00000056234; -. DR Ensembl; ENSBTAT00000064793.2; ENSBTAP00000056234.1; ENSBTAG00000046718.3. DR GeneID; 100126817; -. DR KEGG; bta:100126817; -. DR CTD; 100126817; -. DR VEuPathDB; HostDB:ENSBTAG00000046718; -. DR VGNC; VGNC:35771; SPMIP10. DR eggNOG; ENOG502S426; Eukaryota. DR GeneTree; ENSGT00390000006935; -. DR HOGENOM; CLU_131594_1_0_1; -. DR InParanoid; A8SMG2; -. DR OMA; PKITNNC; -. DR OrthoDB; 5317944at2759; -. DR TreeFam; TF339864; -. DR Proteomes; UP000009136; Chromosome 7. DR Bgee; ENSBTAG00000046718; Expressed in semen and 10 other cell types or tissues. DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW. DR GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central. DR InterPro; IPR027965; SPMIP10. DR PANTHER; PTHR35247; TESTIS-EXPRESSED PROTEIN 43; 1. DR PANTHER; PTHR35247:SF1; TESTIS-EXPRESSED PROTEIN 43; 1. DR Pfam; PF14983; SPMIP10-like; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum; KW Reference proteome. FT CHAIN 1..133 FT /note="Sperm-associated microtubule inner protein 10" FT /id="PRO_0000321823" SQ SEQUENCE 133 AA; 15181 MW; 38EA56A5D7F8D9DC CRC64; MASGKDTCPI LPKLTNNCSD ENSDKLANKC EIHLPRFSLK QGMIPRHYVM PWKQNMKFRN VNLKHAEACG IHAGPLEDSL FLDHSERLCH GEDRKVVLKK GPPEIKIADM PLHSPLSRYQ STVISHGFRR RLI //