ID GOB1_BRUMA Reviewed; 492 AA. AC A8NS89; DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot. DT 15-JAN-2008, sequence version 1. DT 06-MAR-2013, entry version 18. DE RecName: Full=Trehalose-phosphatase; DE EC=3.1.3.12; DE AltName: Full=Trehalose-6-phosphate phosphatase; DE Short=TPP; GN ORFNames=Bm1_08695; OS Brugia malayi (Filarial nematode worm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida; OC Filarioidea; Onchocercidae; Brugia. OX NCBI_TaxID=6279; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17885136; DOI=10.1126/science.1145406; RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., RA Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., RA Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., RA Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H., RA Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., RA Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., RA Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., RA Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., RA Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., RA Blaxter M.L., Scott A.L.; RT "Draft genome of the filarial nematode parasite Brugia malayi."; RL Science 317:1756-1760(2007). CC -!- FUNCTION: Catalyzes the hydrolsysis of trehalose 6-phosphate to CC trehalose and phosphate (By similarity). CC -!- CATALYTIC ACTIVITY: Trehalose 6-phosphate + H(2)O = trehalose + CC phosphate. CC -!- SIMILARITY: Belongs to the gob-1 trehalose phosphatase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS237867; EDP37955.1; -; Genomic_DNA. DR RefSeq; XP_001893209.1; XM_001893174.1. DR GeneID; 6096670; -. DR KEGG; bmy:Bm1_08695; -. DR CTD; 6096670; -. DR InParanoid; A8NS89; -. DR GO; GO:0004805; F:trehalose-phosphatase activity; IEA:EC. DR Gene3D; 3.40.50.1000; -; 3. DR InterPro; IPR023214; HAD-like_dom. PE 3: Inferred from homology; KW Complete proteome; Hydrolase. FT CHAIN 1 492 Trehalose-phosphatase. FT /FTId=PRO_0000385170. SQ SEQUENCE 492 AA; 55119 MW; A07618B5C47178E5 CRC64; MTETVTDQGK QRSSKLQKNE AAKDEQVEGK GKETLESGTD KSAEQNSSLL VGQPDVIDND NVQTVDDFKN LMYKMQETRR AIVFALLNEK DLTKDDVEIL KRAYEKLTDN QTHSFQREMC TLTTKLSVNI GDETRGLEKD LKYLDALMNI RREEPNLLWP IIMSRVDLFS ILANYHPKGK ETFLKEYEDT VKFLKTFISS EAITGKKPIF ITDWDGTMKD YCSQYATNLQ PVYSAVGMTR FAASFTRISA VLTAGPLRGP GILDLTAMPI DGPVMFSGSW GREWWLSGKR VVHQDGITDE GFNALQRLDD EMKDLLHTSD YAPFALVGSG VQRKVDRLTL GVQTVCHHVT SELSNRYQMA VKERMHRVDP NSQILVFDPS TELEVEVVAH NSGIIWNKGN GVERLIKSLG DSLQSPGKIL ICGDTLSDIP MVRQAVKQNP DGVLAIFVGA KMSLREEVKQ VIGDESRCCF VSCPDVIHAA MSQILNEHCI GK //