ID A8N6F5_COPC7 Unreviewed; 874 AA. AC A8N6F5; DT 15-JAN-2008, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 2. DT 29-MAY-2024, entry version 61. DE SubName: Full=DUF221 family protein {ECO:0000313|EMBL:EAU91569.2}; GN ORFNames=CC1G_02058 {ECO:0000313|EMBL:EAU91569.2}; OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) OS (Inky cap fungus) (Hormographiella aspergillata). OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis. OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU91569.2, ECO:0000313|Proteomes:UP000001861}; RN [1] {ECO:0000313|EMBL:EAU91569.2, ECO:0000313|Proteomes:UP000001861} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003 RC {ECO:0000313|Proteomes:UP000001861}; RX PubMed=20547848; DOI=10.1073/pnas.1003391107; RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M., RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S., RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J., RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C., RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J., RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O., RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M., RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q., RA Zolan M.E., Pukkila P.J.; RT "Insights into evolution of multicellular fungi from the assembled RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)."; RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. CC {ECO:0000256|ARBA:ARBA00007779}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EAU91569.2}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACS02000003; EAU91569.2; -; Genomic_DNA. DR RefSeq; XP_001830422.2; XM_001830370.2. DR AlphaFoldDB; A8N6F5; -. DR GeneID; 6006864; -. DR KEGG; cci:CC1G_02058; -. DR VEuPathDB; FungiDB:CC1G_02058; -. DR eggNOG; KOG1134; Eukaryota. DR HOGENOM; CLU_002458_2_0_1; -. DR InParanoid; A8N6F5; -. DR OMA; DPTQVIW; -. DR OrthoDB; 54187at2759; -. DR Proteomes; UP000001861; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro. DR InterPro; IPR045122; Csc1-like. DR InterPro; IPR003864; CSC1/OSCA1-like_7TM. DR InterPro; IPR027815; CSC1/OSCA1-like_cyt. DR InterPro; IPR032880; Csc1/OSCA1-like_N. DR InterPro; IPR022257; PHM7_ext. DR PANTHER; PTHR13018:SF143; PHOSPHATE METABOLISM PROTEIN 7; 1. DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1. DR Pfam; PF14703; PHM7_cyt; 1. DR Pfam; PF12621; PHM7_ext; 1. DR Pfam; PF02714; RSN1_7TM; 1. DR Pfam; PF13967; RSN1_TM; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001861}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 17..39 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 99..118 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 147..166 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 377..397 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 427..447 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 467..485 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 522..551 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 557..581 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 593..618 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 624..647 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 17..168 FT /note="CSC1/OSCA1-like N-terminal transmembrane" FT /evidence="ECO:0000259|Pfam:PF13967" FT DOMAIN 191..346 FT /note="CSC1/OSCA1-like cytosolic" FT /evidence="ECO:0000259|Pfam:PF14703" FT DOMAIN 488..616 FT /note="CSC1/OSCA1-like 7TM region" FT /evidence="ECO:0000259|Pfam:PF02714" FT DOMAIN 793..865 FT /note="10TM putative phosphate transporter extracellular FT tail" FT /evidence="ECO:0000259|Pfam:PF12621" FT REGION 268..287 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 706..728 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 749..811 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 273..287 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 706..722 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 753..767 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 874 AA; 98445 MW; 3AC0D06F662D6844 CRC64; MATIDRQKAS QSNSTTAFVT ALAVNAGLLA AEVGVFLILK TKLWRVYSPR AYLPPPDKRA DELPGGLWRW FPALLRSPTK EIIQKNGLDA YMFLRFIKLL VWIFLAFTIV TFLVIIPADA VNIQSTLTGV ERISWSNIVD PRDQHRFAAH VIVVYVLTAF VVYMIHREMH HFVQLRHQFL LSPSHSKLAQ SRTVLITSIP EELGNEQDIK TFASFVPGGV DRVWLYRDTK TLNELFERRQ ELCELLEAAE SALLKQATKA WRKRVKAHAK AQRKKPRDVE HNPTELAKPE PSIELLQDLV PPHKRPMHRT GLLRLVGTKV DTINWCKEEI AKINVSIAEL RKDNSEHKWM DAHPKDIVWN NLDDGALEMK GRYITSWMAT VGLIIAWTFP VSFIGTLSNL GELCTDVKWL AWVCDLPDVV RGLIEGVLPP GLLAVLFALL PFILQALAWY ECIARYSLIS VSVYKRFYFF LLIHGFLVVT LTSGLTNVTQ GLAGAGNALA QFVPLILHYV RKWFLGRTPR QAYAVTFMMP AADFGVVLPR LSLLATIAFA YSVLSPLINL LALLSFGMFY IAWKFLFVQV FDQPDETETG GMYFPMAVGN LFVGLYIEHI CLAALFFMRA PDEGAGAVVK AIFMLVLLGL TAVAQLFMSN SFDHLIHYLP MSLATKKMAK KFEKEKRRRT GTMLPEDNEE ELDLFSRSRI RSVRRRVKKT VEEIKGRSSD DSAKAPLADG AAEMAAVTSL EMLERHMGGE LQRQKTNDST HSQHSNHSNR SNRSDNKPKV VFDAPAPRVT MSDDSDDSDE EAADDHAFDH PSTYQEQAWI WIPKDPLGLS EVLAKDLRSA GVDASDVGAF MDEHGVVEVR RNPPDEEWAG GHDA //