ID A8JRC7_DROME Unreviewed; 1063 AA. AC A8JRC7; DT 04-DEC-2007, integrated into UniProtKB/TrEMBL. DT 04-DEC-2007, sequence version 1. DT 18-JAN-2017, entry version 90. DE SubName: Full=Lipophorin receptor 2, isoform G {ECO:0000313|EMBL:ABW08770.1}; GN Name=LpR2 {ECO:0000313|EMBL:ABW08770.1, GN ECO:0000313|FlyBase:FBgn0051092}; GN ORFNames=CG31092 {ECO:0000313|FlyBase:FBgn0051092}, Dmel_CG31092 GN {ECO:0000313|EMBL:ABW08770.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Contains 2 EGF-like domain. {ECO:0000256|PROSITE- CC ProRule:PRU00076}. CC -!- SIMILARITY: Contains 5 LDL-receptor class B repeat. CC {ECO:0000256|PROSITE-ProRule:PRU00461}. CC -!- SIMILARITY: Contains 8 LDL-receptor class A domain. CC {ECO:0000256|PROSITE-ProRule:PRU00124}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABW08770.1; -; Genomic_DNA. DR RefSeq; NP_001097930.1; NM_001104460.2. DR UniGene; Dm.10816; -. DR ProteinModelPortal; A8JRC7; -. DR SMR; A8JRC7; -. DR STRING; 7227.FBpp0112298; -. DR PaxDb; A8JRC7; -. DR EnsemblMetazoa; FBtr0113388; FBpp0112300; FBgn0051092. DR GeneID; 43105; -. DR UCSC; CG31092-RG; d. melanogaster. DR CTD; 43105; -. DR FlyBase; FBgn0051092; LpR2. DR eggNOG; KOG1215; Eukaryota. DR eggNOG; ENOG410YQ6J; LUCA. DR GeneTree; ENSGT00760000118968; -. DR OrthoDB; EOG091G01MX; -. DR Reactome; R-DME-171052; LDL-mediated lipid transport. DR Reactome; R-DME-432142; Platelet sensitization by LDL. DR Reactome; R-DME-8856825; Cargo recognition for clathrin-mediated endocytosis. DR Reactome; R-DME-8856828; Clathrin-mediated endocytosis. DR Reactome; R-DME-8866427; VLDLR internalisation and degradation. DR GenomeRNAi; 43105; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0051092; -. DR ExpressionAtlas; A8JRC7; differential. DR Genevisible; A8JRC7; DM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0071813; F:lipoprotein particle binding; IPI:FlyBase. DR GO; GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase. DR GO; GO:0032370; P:positive regulation of lipid transport; IMP:FlyBase. DR Gene3D; 2.120.10.30; -; 1. DR Gene3D; 4.10.400.10; -; 8. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF07645; EGF_CA; 1. DR Pfam; PF00057; Ldl_recept_a; 8. DR Pfam; PF00058; Ldl_recept_b; 2. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 6. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00192; LDLa; 8. DR SMART; SM00135; LY; 5. DR SUPFAM; SSF57184; SSF57184; 2. DR SUPFAM; SSF57424; SSF57424; 8. DR PROSITE; PS00010; ASX_HYDROXYL; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS01209; LDLRA_1; 8. DR PROSITE; PS50068; LDLRA_2; 8. DR PROSITE; PS51120; LDLRB; 5. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Membrane {ECO:0000256|SAAS:SAAS00492762, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ABW08770.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Transmembrane {ECO:0000256|SAAS:SAAS00492834, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00492819, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 985 1007 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 522 562 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 563 603 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT REPEAT 649 692 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 693 735 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 736 779 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 780 824 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 825 867 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DISULFID 193 205 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 200 218 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 236 248 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 243 261 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 296 311 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 316 328 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 323 341 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 335 350 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 356 368 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 363 381 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 441 453 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 448 466 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 460 475 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 492 510 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 567 577 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1063 AA; 116943 MW; 156FCFE8393FE9BC CRC64; MATTCMPHFT EYFQTTTQSE LTTNESANSR SSSSSSGCRE PSKTSGFFYS ASTHYQSKVQ QLISFSFTSS FHLLFITCIL SISKFCNAAA VNAAHVTAAT PTASEIMHNL SGSALLERLK ASTLGPTLDQ LKHLAPAAAN SISPGTGSGM GIGMGHFGSS INSVLNGNPL KFLNVSGKIG TPLDISLGLS NYCDEKQFQC STGECIPIRF VCDGSSDCPD HSDERLEECK FTESTCSQEQ FRCGNGKCIP RRWVCDREND CADGSDESTS QCRGLCSSLM FMCKNGEQCI HREFMCDGDQ DCRDGSDELE CGNRTCRSDE FTCGNGRCIQ NRFKCDDDDD CGDGSDEKNC GEKAKCGSNF FACKSGPCIP NQWVCDGDSD CRNGEDEMQN CTVSLLNFCQ AGEFQCSDRI TCLHKSWVCD GEADCPDGED ESQSNCLKVS CRPDQFQCND QSCIAGHLTC NGKRDCADGS DEIMCDISAT PRTCNATTEF DCGGGLCIPN AKVCNRRKDC PNGEDEPAGK CGINECSSKN GGCMHQCVNL EVGYRCECHD GYKLGADQHT CVDIDECETP GICSQVCVNE IGAFKCECEA GYMRLLKNHT RCKASEGHAS LLLARRHDIR KIALDRPEMT SIVNSTKAAT ALDFVFRTGM IFWSDVATQS IYKAPIDEGN DRTVVLTKSS VTSDGLAVDW IYNHVYFTDT HKCTIELTNF EGSMGKVLVK DSLDIPRSIA LDPIEGWMYW SDWGASPRIE RAGMDGTHRT AIITYDVKWP NGITLDLVQK RLYWVDGKLN TISSSNYDGS QRHQVLYSGE YLRHPFSITT FEDYVYWTDW DKQAVFKANK FNGMDVEPVT ATHMLEHPMV VHVYHPYRQP DGVNHCQSVN GHCSHLCLPA PRINERSPRI SCACPTGLKL MPDGLMCVED LGIPTVRPTA PMHRTIEQSS NSTTKLPQDG YSETPVETKT GNNRTDTSNQ VHKSDAESEN DYVEIALHVI ASLAGTALVA SVIYVVYRRC TRAVNSMNFE NPVYHKTTED HFSLEKNGTP HIYAAANDEE AVNPLFKSGT ECV //