ID A8JRC7_DROME Unreviewed; 1063 AA. AC A8JRC7; DT 04-DEC-2007, integrated into UniProtKB/TrEMBL. DT 04-DEC-2007, sequence version 1. DT 01-OCT-2014, entry version 66. DE SubName: Full=LpR2, isoform G {ECO:0000313|EMBL:ABW08770.1}; GN Name=LpR2 {ECO:0000313|EMBL:ABW08770.1, GN ECO:0000313|FlyBase:FBgn0051092}; GN ORFNames=CG31092 {ECO:0000313|FlyBase:FBgn0051092}, Dmel_CG31092 GN {ECO:0000313|EMBL:ABW08770.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABW08770.1; -; Genomic_DNA. DR RefSeq; NP_001097930.1; NM_001104460.2. DR UniGene; Dm.10816; -. DR ProteinModelPortal; A8JRC7; -. DR SMR; A8JRC7; 193-909. DR EnsemblMetazoa; FBtr0113388; FBpp0112300; FBgn0051092. DR GeneID; 43105; -. DR KEGG; dme:Dmel_CG31092; -. DR UCSC; CG31092-RG; d. melanogaster. DR CTD; 43105; -. DR FlyBase; FBgn0051092; LpR2. DR GeneTree; ENSGT00740000114992; -. DR Reactome; REACT_181664; LDL-mediated lipid transport. DR Reactome; REACT_221889; Platelet sensitization by LDL. DR GenomeRNAi; 43105; -. DR NextBio; 832243; -. DR Bgee; A8JRC7; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase. DR Gene3D; 2.120.10.30; -; 1. DR Gene3D; 4.10.400.10; -; 8. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR000742; EG-like_dom. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_N_dom. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF07645; EGF_CA; 1. DR Pfam; PF00057; Ldl_recept_a; 8. DR Pfam; PF00058; Ldl_recept_b; 2. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00192; LDLa; 8. DR SMART; SM00135; LY; 5. DR SUPFAM; SSF57184; SSF57184; 2. DR SUPFAM; SSF57424; SSF57424; 8. DR PROSITE; PS00010; ASX_HYDROXYL; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS01209; LDLRA_1; 8. DR PROSITE; PS50068; LDLRA_2; 8. DR PROSITE; PS51120; LDLRB; 5. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00144437}; KW EGF-like domain {ECO:0000256|RuleBase:RU000459, KW ECO:0000256|SAAS:SAAS00144411}; KW Membrane {ECO:0000256|SAAS:SAAS00144399}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|SAAS:SAAS00144431}; KW Transmembrane {ECO:0000256|SAAS:SAAS00144472}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00144429}. SQ SEQUENCE 1063 AA; 116943 MW; 156FCFE8393FE9BC CRC64; MATTCMPHFT EYFQTTTQSE LTTNESANSR SSSSSSGCRE PSKTSGFFYS ASTHYQSKVQ QLISFSFTSS FHLLFITCIL SISKFCNAAA VNAAHVTAAT PTASEIMHNL SGSALLERLK ASTLGPTLDQ LKHLAPAAAN SISPGTGSGM GIGMGHFGSS INSVLNGNPL KFLNVSGKIG TPLDISLGLS NYCDEKQFQC STGECIPIRF VCDGSSDCPD HSDERLEECK FTESTCSQEQ FRCGNGKCIP RRWVCDREND CADGSDESTS QCRGLCSSLM FMCKNGEQCI HREFMCDGDQ DCRDGSDELE CGNRTCRSDE FTCGNGRCIQ NRFKCDDDDD CGDGSDEKNC GEKAKCGSNF FACKSGPCIP NQWVCDGDSD CRNGEDEMQN CTVSLLNFCQ AGEFQCSDRI TCLHKSWVCD GEADCPDGED ESQSNCLKVS CRPDQFQCND QSCIAGHLTC NGKRDCADGS DEIMCDISAT PRTCNATTEF DCGGGLCIPN AKVCNRRKDC PNGEDEPAGK CGINECSSKN GGCMHQCVNL EVGYRCECHD GYKLGADQHT CVDIDECETP GICSQVCVNE IGAFKCECEA GYMRLLKNHT RCKASEGHAS LLLARRHDIR KIALDRPEMT SIVNSTKAAT ALDFVFRTGM IFWSDVATQS IYKAPIDEGN DRTVVLTKSS VTSDGLAVDW IYNHVYFTDT HKCTIELTNF EGSMGKVLVK DSLDIPRSIA LDPIEGWMYW SDWGASPRIE RAGMDGTHRT AIITYDVKWP NGITLDLVQK RLYWVDGKLN TISSSNYDGS QRHQVLYSGE YLRHPFSITT FEDYVYWTDW DKQAVFKANK FNGMDVEPVT ATHMLEHPMV VHVYHPYRQP DGVNHCQSVN GHCSHLCLPA PRINERSPRI SCACPTGLKL MPDGLMCVED LGIPTVRPTA PMHRTIEQSS NSTTKLPQDG YSETPVETKT GNNRTDTSNQ VHKSDAESEN DYVEIALHVI ASLAGTALVA SVIYVVYRRC TRAVNSMNFE NPVYHKTTED HFSLEKNGTP HIYAAANDEE AVNPLFKSGT ECV //