ID A8JRC7_DROME Unreviewed; 1063 AA. AC A8JRC7; DT 04-DEC-2007, integrated into UniProtKB/TrEMBL. DT 04-DEC-2007, sequence version 1. DT 26-JUN-2013, entry version 57. DE SubName: Full=LpR2, isoform G; GN Name=LpR2; ORFNames=CG31092, Dmel_CG31092; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABW08770.1; -; Genomic_DNA. DR RefSeq; NP_001097930.1; NM_001104460.2. DR UniGene; Dm.10816; -. DR ProteinModelPortal; A8JRC7; -. DR SMR; A8JRC7; 193-909. DR EnsemblMetazoa; FBtr0113388; FBpp0112300; FBgn0051092. DR GeneID; 43105; -. DR KEGG; dme:Dmel_CG31092; -. DR UCSC; CG31092-RG; d. melanogaster. DR CTD; 43105; -. DR FlyBase; FBgn0051092; LpR2. DR GeneTree; ENSGT00700000104037; -. DR GenomeRNAi; 43105; -. DR NextBio; 832243; -. DR Bgee; A8JRC7; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase. DR Gene3D; 2.120.10.30; -; 1. DR Gene3D; 4.10.400.10; -; 8. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR026823; cEGF. DR InterPro; IPR000742; EG-like_dom. DR InterPro; IPR001881; EGF-like_Ca-bd. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF12662; cEGF; 1. DR Pfam; PF00057; Ldl_recept_a; 8. DR Pfam; PF00058; Ldl_recept_b; 2. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00192; LDLa; 8. DR SMART; SM00135; LY; 5. DR SUPFAM; SSF57424; LDL_rcpt_classA_cys-rich; 8. DR PROSITE; PS00010; ASX_HYDROXYL; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS01209; LDLRA_1; 8. DR PROSITE; PS50068; LDLRA_2; 8. DR PROSITE; PS51120; LDLRB; 5. PE 4: Predicted; KW Complete proteome; Disulfide bond; EGF-like domain; Membrane; KW Reference proteome; Repeat; Transmembrane; Transmembrane helix. SQ SEQUENCE 1063 AA; 116943 MW; 156FCFE8393FE9BC CRC64; MATTCMPHFT EYFQTTTQSE LTTNESANSR SSSSSSGCRE PSKTSGFFYS ASTHYQSKVQ QLISFSFTSS FHLLFITCIL SISKFCNAAA VNAAHVTAAT PTASEIMHNL SGSALLERLK ASTLGPTLDQ LKHLAPAAAN SISPGTGSGM GIGMGHFGSS INSVLNGNPL KFLNVSGKIG TPLDISLGLS NYCDEKQFQC STGECIPIRF VCDGSSDCPD HSDERLEECK FTESTCSQEQ FRCGNGKCIP RRWVCDREND CADGSDESTS QCRGLCSSLM FMCKNGEQCI HREFMCDGDQ DCRDGSDELE CGNRTCRSDE FTCGNGRCIQ NRFKCDDDDD CGDGSDEKNC GEKAKCGSNF FACKSGPCIP NQWVCDGDSD CRNGEDEMQN CTVSLLNFCQ AGEFQCSDRI TCLHKSWVCD GEADCPDGED ESQSNCLKVS CRPDQFQCND QSCIAGHLTC NGKRDCADGS DEIMCDISAT PRTCNATTEF DCGGGLCIPN AKVCNRRKDC PNGEDEPAGK CGINECSSKN GGCMHQCVNL EVGYRCECHD GYKLGADQHT CVDIDECETP GICSQVCVNE IGAFKCECEA GYMRLLKNHT RCKASEGHAS LLLARRHDIR KIALDRPEMT SIVNSTKAAT ALDFVFRTGM IFWSDVATQS IYKAPIDEGN DRTVVLTKSS VTSDGLAVDW IYNHVYFTDT HKCTIELTNF EGSMGKVLVK DSLDIPRSIA LDPIEGWMYW SDWGASPRIE RAGMDGTHRT AIITYDVKWP NGITLDLVQK RLYWVDGKLN TISSSNYDGS QRHQVLYSGE YLRHPFSITT FEDYVYWTDW DKQAVFKANK FNGMDVEPVT ATHMLEHPMV VHVYHPYRQP DGVNHCQSVN GHCSHLCLPA PRINERSPRI SCACPTGLKL MPDGLMCVED LGIPTVRPTA PMHRTIEQSS NSTTKLPQDG YSETPVETKT GNNRTDTSNQ VHKSDAESEN DYVEIALHVI ASLAGTALVA SVIYVVYRRC TRAVNSMNFE NPVYHKTTED HFSLEKNGTP HIYAAANDEE AVNPLFKSGT ECV //