ID A8JRC7_DROME Unreviewed; 1063 AA. AC A8JRC7; DT 04-DEC-2007, integrated into UniProtKB/TrEMBL. DT 04-DEC-2007, sequence version 1. DT 14-DEC-2022, entry version 131. DE SubName: Full=Lipophorin receptor 2, isoform G {ECO:0000313|EMBL:ABW08770.1}; GN Name=LpR2 {ECO:0000313|EMBL:ABW08770.1, GN ECO:0000313|FlyBase:FBgn0051092}; GN Synonyms=CG4823 {ECO:0000313|EMBL:ABW08770.1}, CG4834 GN {ECO:0000313|EMBL:ABW08770.1}, Dmel\CG31092 GN {ECO:0000313|EMBL:ABW08770.1}, LDLR {ECO:0000313|EMBL:ABW08770.1}, GN Lpr2 {ECO:0000313|EMBL:ABW08770.1}, lpr2 GN {ECO:0000313|EMBL:ABW08770.1}, Lpr2-E {ECO:0000313|EMBL:ABW08770.1}; GN ORFNames=CG31092 {ECO:0000313|EMBL:ABW08770.1, GN ECO:0000313|FlyBase:FBgn0051092}, Dmel_CG31092 GN {ECO:0000313|EMBL:ABW08770.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ABW08770.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABW08770.1; -; Genomic_DNA. DR RefSeq; NP_001097930.1; NM_001104460.2. DR AlphaFoldDB; A8JRC7; -. DR SMR; A8JRC7; -. DR DNASU; 43105; -. DR EnsemblMetazoa; FBtr0113388; FBpp0112300; FBgn0051092. DR GeneID; 43105; -. DR UCSC; CG31092-RG; d. melanogaster. DR AGR; FB:FBgn0051092; -. DR CTD; 43105; -. DR FlyBase; FBgn0051092; LpR2. DR VEuPathDB; VectorBase:FBgn0051092; -. DR GeneTree; ENSGT00940000165170; -. DR BioGRID-ORCS; 43105; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 43105; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0051092; Expressed in wing disc and 32 other tissues. DR ExpressionAtlas; A8JRC7; baseline and differential. DR Genevisible; A8JRC7; DM. DR GO; GO:0005769; C:early endosome; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0071813; F:lipoprotein particle binding; IPI:FlyBase. DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IBA:GO_Central. DR GO; GO:0032370; P:positive regulation of lipid transport; IMP:FlyBase. DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central. DR CDD; cd00112; LDLa; 7. DR Gene3D; 2.120.10.30; -; 1. DR Gene3D; 4.10.400.10; -; 8. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR026823; cEGF. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF12662; cEGF; 1. DR Pfam; PF00057; Ldl_recept_a; 8. DR Pfam; PF00058; Ldl_recept_b; 2. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 6. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00192; LDLa; 8. DR SMART; SM00135; LY; 5. DR SUPFAM; SSF57184; Growth factor receptor domain; 1. DR SUPFAM; SSF57424; LDL receptor-like module; 8. DR PROSITE; PS00010; ASX_HYDROXYL; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS01209; LDLRA_1; 6. DR PROSITE; PS50068; LDLRA_2; 8. DR PROSITE; PS51120; LDLRB; 4. PE 4: Predicted; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536}; KW Endocytosis {ECO:0000256|ARBA:ARBA00022583}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABW08770.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 985..1007 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 546..561 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS01186" FT REPEAT 649..692 FT /note="LDL-receptor class B" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461" FT REPEAT 693..735 FT /note="LDL-receptor class B" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461" FT REPEAT 736..779 FT /note="LDL-receptor class B" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461" FT REPEAT 780..824 FT /note="LDL-receptor class B" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461" FT REGION 19..41 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 934..977 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 934..969 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 193..205 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 200..218 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 236..248 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 243..261 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 296..311 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 316..328 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 323..341 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 335..350 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 356..368 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 363..381 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 441..453 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 448..466 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 460..475 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" FT DISULFID 492..510 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124" SQ SEQUENCE 1063 AA; 116943 MW; 156FCFE8393FE9BC CRC64; MATTCMPHFT EYFQTTTQSE LTTNESANSR SSSSSSGCRE PSKTSGFFYS ASTHYQSKVQ QLISFSFTSS FHLLFITCIL SISKFCNAAA VNAAHVTAAT PTASEIMHNL SGSALLERLK ASTLGPTLDQ LKHLAPAAAN SISPGTGSGM GIGMGHFGSS INSVLNGNPL KFLNVSGKIG TPLDISLGLS NYCDEKQFQC STGECIPIRF VCDGSSDCPD HSDERLEECK FTESTCSQEQ FRCGNGKCIP RRWVCDREND CADGSDESTS QCRGLCSSLM FMCKNGEQCI HREFMCDGDQ DCRDGSDELE CGNRTCRSDE FTCGNGRCIQ NRFKCDDDDD CGDGSDEKNC GEKAKCGSNF FACKSGPCIP NQWVCDGDSD CRNGEDEMQN CTVSLLNFCQ AGEFQCSDRI TCLHKSWVCD GEADCPDGED ESQSNCLKVS CRPDQFQCND QSCIAGHLTC NGKRDCADGS DEIMCDISAT PRTCNATTEF DCGGGLCIPN AKVCNRRKDC PNGEDEPAGK CGINECSSKN GGCMHQCVNL EVGYRCECHD GYKLGADQHT CVDIDECETP GICSQVCVNE IGAFKCECEA GYMRLLKNHT RCKASEGHAS LLLARRHDIR KIALDRPEMT SIVNSTKAAT ALDFVFRTGM IFWSDVATQS IYKAPIDEGN DRTVVLTKSS VTSDGLAVDW IYNHVYFTDT HKCTIELTNF EGSMGKVLVK DSLDIPRSIA LDPIEGWMYW SDWGASPRIE RAGMDGTHRT AIITYDVKWP NGITLDLVQK RLYWVDGKLN TISSSNYDGS QRHQVLYSGE YLRHPFSITT FEDYVYWTDW DKQAVFKANK FNGMDVEPVT ATHMLEHPMV VHVYHPYRQP DGVNHCQSVN GHCSHLCLPA PRINERSPRI SCACPTGLKL MPDGLMCVED LGIPTVRPTA PMHRTIEQSS NSTTKLPQDG YSETPVETKT GNNRTDTSNQ VHKSDAESEN DYVEIALHVI ASLAGTALVA SVIYVVYRRC TRAVNSMNFE NPVYHKTTED HFSLEKNGTP HIYAAANDEE AVNPLFKSGT ECV //