ID A8DRA1_AOTAI Unreviewed; 57 AA. AC A8DRA1; DT 13-NOV-2007, integrated into UniProtKB/TrEMBL. DT 13-NOV-2007, sequence version 1. DT 29-MAY-2024, entry version 30. DE SubName: Full=Interleukin 4 {ECO:0000313|EMBL:ABL85454.1}; DE Flags: Fragment; GN Name=IL4 {ECO:0000313|EMBL:ABL85454.1}; OS Aotus azarai subsp. infulatus (Feline night monkey) (Aotus infulatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae; OC Aotus. OX NCBI_TaxID=867331 {ECO:0000313|EMBL:ABL85454.1}; RN [1] {ECO:0000313|EMBL:ABL85454.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=20943414; DOI=10.1016/j.cyto.2010.09.004; RA Alves F.A., Souza M.T., Goncalves E.C., Schneider M.P., Marinho A.M., RA Muniz J.A., Fragoso S.P., Krieger M.A., Goldenberg S., Daniel-Ribeiro C.T., RA Carvalho L.J.; RT "DNA sequencing of 13 cytokine gene fragments of Aotus infulatus and RT Saimiri sciureus, two non-human primate models for malaria."; RL Cytokine 52:151-155(2010). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ985389; ABL85454.1; -; Genomic_DNA. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0005125; F:cytokine activity; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:InterPro. DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro. DR GO; GO:0031296; P:B cell costimulation; IEA:TreeGrafter. DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:TreeGrafter. DR GO; GO:0002227; P:innate immune response in mucosa; IEA:TreeGrafter. DR GO; GO:0001774; P:microglial cell activation; IEA:TreeGrafter. DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:TreeGrafter. DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IEA:TreeGrafter. DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IEA:TreeGrafter. DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IEA:TreeGrafter. DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:TreeGrafter. DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IEA:TreeGrafter. DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:TreeGrafter. DR GO; GO:0043031; P:negative regulation of macrophage activation; IEA:TreeGrafter. DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:TreeGrafter. DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IEA:TreeGrafter. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:TreeGrafter. DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:TreeGrafter. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:TreeGrafter. DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IEA:TreeGrafter. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:TreeGrafter. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IEA:TreeGrafter. DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IEA:TreeGrafter. DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:TreeGrafter. DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:TreeGrafter. DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:TreeGrafter. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:TreeGrafter. DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IEA:TreeGrafter. DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:TreeGrafter. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:TreeGrafter. DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:TreeGrafter. DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:TreeGrafter. DR GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:TreeGrafter. DR InterPro; IPR002354; IL-4. DR PANTHER; PTHR47401; INTERLEUKIN-4; 1. DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 4: Predicted; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..57 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002718909" FT NON_TER 57 FT /evidence="ECO:0000313|EMBL:ABL85454.1" SQ SEQUENCE 57 AA; 6369 MW; A1DAB31511E993CA CRC64; MGLTPRLLPA LFFLLACAGN FVHGHNCNIA LEEIIRTLSA VTDQKTLXXE FFHSDRC //