ID A8BN64_GIAIC Unreviewed; 1172 AA. AC A8BN64; DT 13-NOV-2007, integrated into UniProtKB/TrEMBL. DT 13-NOV-2007, sequence version 1. DT 11-DEC-2019, entry version 78. DE SubName: Full=Kinesin-14 {ECO:0000313|EMBL:EDO78362.1}; GN ORFNames=GL50803_13797 {ECO:0000313|EMBL:EDO78362.1}; OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia). OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia. OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78362.1, ECO:0000313|Proteomes:UP000001548}; RN [1] {ECO:0000313|EMBL:EDO78362.1, ECO:0000313|Proteomes:UP000001548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548}; RX PubMed=17901334; DOI=10.1126/science.1143837; RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D., RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J., RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U., RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D., RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J., RA Svard S.G., Sogin M.L.; RT "Genomic minimalism in the early diverging intestinal parasite Giardia RT lamblia."; RL Science 317:1921-1926(2007). CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283, CC ECO:0000256|SAAS:SAAS00583243}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EDO78362.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACB02000027; EDO78362.1; -; Genomic_DNA. DR RefSeq; XP_001706036.1; XM_001705984.1. DR EnsemblProtists; EDO78362; EDO78362; GL50803_13797. DR GeneID; 5698921; -. DR KEGG; gla:GL50803_13797; -. DR EuPathDB; GiardiaDB:GL50803_13797; -. DR eggNOG; KOG0239; Eukaryota. DR eggNOG; COG5059; LUCA. DR InParanoid; A8BN64; -. DR OMA; EAQHINT; -. DR OrthoDB; 364605at2759; -. DR Proteomes; UP000001548; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0008017; F:microtubule binding; IEA:InterPro. DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro. DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro. DR Gene3D; 3.40.850.10; -; 1. DR InterPro; IPR027640; Kinesin-like_fam. DR InterPro; IPR001752; Kinesin_motor_dom. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000626; Ubiquitin-like_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR24115; PTHR24115; 1. DR Pfam; PF00225; Kinesin; 1. DR PRINTS; PR00380; KINESINHEAVY. DR SMART; SM00129; KISc; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR PROSITE; PS50067; KINESIN_MOTOR_2; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283, KW ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils}; KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283, KW ECO:0000256|SAAS:SAAS00874053}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283, KW ECO:0000256|SAAS:SAAS00874078}; KW Reference proteome {ECO:0000313|Proteomes:UP000001548}. FT DOMAIN 5..85 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS50053" FT DOMAIN 787..1157 FT /note="Kinesin motor" FT /evidence="ECO:0000259|PROSITE:PS50067" FT NP_BIND 881..888 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283" FT REGION 81..157 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 200..237 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 272..348 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 577..649 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 491..511 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 666..690 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 86..112 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 113..127 FT /note="Basic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 279..318 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 577..638 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1172 AA; 131092 MW; 86C6E8D64D479FE5 CRC64; MSDRLQFTIV HVAERRKFKI TVRVEDVPNV RVRMLKKSIF QATGIPVDCQ ALYLNKQLLS DRMTGSELEL SPETTFVLHT STPAQEEQLD IRDQDNPTDG AAYGDEKSKS RGRSRSRSRS RSRGKGQTSH SNRRDTFGAP LFEGHNGTID GYHPKSMNPP INELNTTAEN LSSPNVINAH MASRDATLQS AATRHFTIPT KDCTRSSPRI QRGSTDKRST TQSIGLCNSS TSSLRDDSVK SIVVKAAGRS SSQQKTCKTS STRSVIKSSY FEPPVSYPKM QSAKSTKKRS QPQKPQTPQK SPHQSGAVTV SPRKRLSNSN YEPCPPKGES YSPTDSPPLI PATNHYTKTK ELTTSRISLT DLHGSDRMYA STQPEFPAKT TKITVPQPSV VDLQLHQSIL SASKGGLLEK PELTPHARLA DSEMEETTAE SKVANDSDYP SFTEDDIELL RQMNDDSRAD IQLVENISVQ NMTRDHASQK QPHLTEELAL VSELQEQVTL IKQEMDTIKR TIASTPTSNA VVDESVLSAH TLQGSKKLCN QFQEAPMSDW SLFKHKYDEE LAALKLEVEQ LRNARDLARS SSNTATHQPP PTSESHLDTT KATRDTFGTL TTDESIELDV NDVARRSSNT TPTTIRPRQS DGPPRPPSAK VLGITKSQQN SSLLAIQTIK QQIEAERAEL TEILQNLEVY SLMDTFFDIE IEIANIEHSN MTQALEESRT SLADIQNKLS YALSKTPTFT PDVRKSAEIS LDYGMFQREY TRLQGLMVVE NKQRKTLHNT LEEMKGSIRV IVRMRPMLQH EKEELKTSKF RSFNYRNAFI FKDEHTLQLK LPYGVASQEN YSFDFYKILD ETKTQEDVFH DMSHLLKSVI DGYNVCVLAY GCTGSGKTFT LIGDDSETAV AESVVMSMQK DPEEKNPYER LGLLPRSIVE LFNLIEADTS QSQRYELRCA MIEHYLDNIL DLLHTEDDTR TQLPSFNSDK LVVRQTAKGE TYIQNLSYKT VASAEELVGY LGYGLERRHI AATKLNSLSS RSHTVFLIEI TSYRETAKGT RTARSVLTFA DLAGSENVTK SHSNGLRLKE AQHINTSLCA LGDVIAALSR KKVASYVPYR NNKLTMILQQ SLGNNSKTLL FANISPLPNL LYETLSTLSF AARVKNVKNV AVKNLTSIES DQ //