ID LPXD_FRATF Reviewed; 337 AA. AC A7NAP3; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 02-OCT-2007, sequence version 1. DT 18-SEP-2013, entry version 41. DE RecName: Full=UDP-3-O-acylglucosamine N-acyltransferase; DE EC=2.3.1.-; GN Name=lpxD; OrderedLocusNames=FTA_0570; OS Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA). OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; OC Francisellaceae; Francisella. OX NCBI_TaxID=458234; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FTNF002-00 / FTA; RX PubMed=19756146; DOI=10.1371/journal.pone.0007041; RA Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., RA Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., RA Zhou L.W., Lion C., Dempsey M.P.; RT "Complete genome sequence of Francisella tularensis subspecies RT holarctica FTNF002-00."; RL PLoS ONE 4:E7041-E7041(2009). CC -!- FUNCTION: Catalyzes the N-acylation of UDP-3-O-acylglucosamine CC using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the CC biosynthesis of lipid A, a phosphorylated glycolipid that anchors CC the lipopolysaccharide to the outer membrane of the cell (By CC similarity). CC -!- CATALYTIC ACTIVITY: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + CC UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D- CC glucosamine + [acyl-carrier-protein]. CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A CC biosynthesis. CC -!- SUBUNIT: Homotrimer (By similarity). CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family. CC LpxD subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000803; ABU61046.1; -; Genomic_DNA. DR RefSeq; YP_001428002.1; NC_009749.1. DR ProteinModelPortal; A7NAP3; -. DR STRING; 119857.FTL_0537; -. DR EnsemblBacteria; ABU61046; ABU61046; FTA_0570. DR GeneID; 5523768; -. DR KEGG; fta:FTA_0570; -. DR PATRIC; 17946445; VBIFraTul129798_0598. DR eggNOG; COG1044; -. DR HOGENOM; HOG000294339; -. DR KO; K02536; -. DR OMA; SYPAKIM; -. DR ProtClustDB; PRK00892; -. DR BioCyc; FTUL458234:GH31-538-MONOMER; -. DR UniPathway; UPA00973; -. DR GO; GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:HAMAP. DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00523; LpxD; 1; -. DR InterPro; IPR001451; Hexapep_transf. DR InterPro; IPR018357; Hexapep_transf_CS. DR InterPro; IPR011004; Trimer_LpxA-like. DR InterPro; IPR007691; UDP-3-O_GlcNAc_AcTrfase. DR InterPro; IPR020573; UDP_GlcNAc_AcTrfase_non-rep. DR Pfam; PF00132; Hexapep; 4. DR Pfam; PF04613; LpxD; 1. DR SUPFAM; SSF51161; Trimer_LpxA_like; 1. DR TIGRFAMs; TIGR01853; lipid_A_lpxD; 1. DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2. PE 3: Inferred from homology; KW Acyltransferase; Complete proteome; Lipid A biosynthesis; KW Lipid biosynthesis; Lipid metabolism; Repeat; Transferase. FT CHAIN 1 337 UDP-3-O-acylglucosamine N- FT acyltransferase. FT /FTId=PRO_1000050940. FT ACT_SITE 238 238 Proton acceptor (By similarity). SQ SEQUENCE 337 AA; 35443 MW; F30AA4F35E8EADA3 CRC64; MYSLDFLASK LDGEVKGDKN VEIKKIATLS QAGEGDISFC TNPKYLKALS ETKASAVLIT EEVLEFCNTN AVVLSNPYMA LAKVMELFDK SPRPDGKIHS KAVIAASAII GENVTIGANA VVGENVVIGD NVYIGACATI DNGTKIGNDT LIKSNVSIAH DVVIGTGCII HQNAVIGCDG FGNARDEDGS WTKIPQLGRV IIEDDVEIGS GTTVDRGAID DTIIKKGARI DNLVQIAHNV VIGRNTALAG VTAVAGSTTI GDNCLIGGQS AITGHISICD NTIIGGASNI GKSITKPGMY YAAFEAKPRI QWGRFVAKLA KIDTLITKVK QLEEKIK //