ID LPXD_FRATF Reviewed; 337 AA. AC A7NAP3; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 02-OCT-2007, sequence version 1. DT 31-MAY-2011, entry version 25. DE RecName: Full=UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; DE EC=2.3.1.-; GN Name=lpxD; OrderedLocusNames=FTA_0570; OS Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA). OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; OC Francisellaceae; Francisella. OX NCBI_TaxID=458234; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FTNF002-00 / FTA; RX PubMed=19756146; DOI=10.1371/journal.pone.0007041; RA Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., RA Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., RA Zhou L.W., Lion C., Dempsey M.P.; RT "Complete genome sequence of Francisella tularensis subspecies RT holarctica FTNF002-00."; RL PLoS ONE 4:E7041-E7041(2009). CC -!- CATALYTIC ACTIVITY: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + CC (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3- CC hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. CC -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid CC IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and CC UDP-N-acetyl-alpha-D-glucosamine: step 3/6. CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family. CC LpxD subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000803; ABU61046.1; -; Genomic_DNA. DR RefSeq; YP_001428002.1; NC_009749.1. DR ProteinModelPortal; A7NAP3; -. DR SMR; A7NAP3; 2-337. DR STRING; A7NAP3; -. DR GeneID; 5523768; -. DR GenomeReviews; CP000803_GR; FTA_0570. DR KEGG; fta:FTA_0570; -. DR eggNOG; COG1044; -. DR HOGENOM; HBG469615; -. DR OMA; AKIMKSA; -. DR ProtClustDB; PRK00892; -. DR BioCyc; FTUL458234:FTA_0570-MONOMER; -. DR GO; GO:0008415; F:acyltransferase activity; IEA:UniProtKB-KW. DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW. DR HAMAP; MF_00523; LpxD; 1; -. DR InterPro; IPR001451; Hexapep_transf. DR InterPro; IPR018357; Hexapep_transf_CS. DR InterPro; IPR011004; Trimer_LpxA-like. DR InterPro; IPR007691; UDP-3-O_GlcNAc_AcTrfase. DR InterPro; IPR020573; UDP_GlcNAc_AcTrfase_non-rep. DR Pfam; PF00132; Hexapep; 3. DR Pfam; PF04613; LpxD; 1. DR SUPFAM; SSF51161; Trimer_LpxA_like; 1. DR TIGRFAMs; TIGR01853; Lipid_A_lpxD; 1. DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2. PE 3: Inferred from homology; KW Acyltransferase; Complete proteome; Lipid A biosynthesis; KW Lipid synthesis; Repeat; Transferase. FT CHAIN 1 337 UDP-3-O-[3-hydroxymyristoyl] glucosamine FT N-acyltransferase. FT /FTId=PRO_1000050940. SQ SEQUENCE 337 AA; 35443 MW; F30AA4F35E8EADA3 CRC64; MYSLDFLASK LDGEVKGDKN VEIKKIATLS QAGEGDISFC TNPKYLKALS ETKASAVLIT EEVLEFCNTN AVVLSNPYMA LAKVMELFDK SPRPDGKIHS KAVIAASAII GENVTIGANA VVGENVVIGD NVYIGACATI DNGTKIGNDT LIKSNVSIAH DVVIGTGCII HQNAVIGCDG FGNARDEDGS WTKIPQLGRV IIEDDVEIGS GTTVDRGAID DTIIKKGARI DNLVQIAHNV VIGRNTALAG VTAVAGSTTI GDNCLIGGQS AITGHISICD NTIIGGASNI GKSITKPGMY YAAFEAKPRI QWGRFVAKLA KIDTLITKVK QLEEKIK //