ID A7K6Y5_HUMAN Unreviewed; 633 AA. AC A7K6Y5; DT 11-SEP-2007, integrated into UniProtKB/TrEMBL. DT 11-SEP-2007, sequence version 1. DT 29-MAY-2024, entry version 127. DE SubName: Full=CDK5 and Abl enzyme substrate 1 {ECO:0000313|EMBL:ABL77400.1}; DE SubName: Full=Cdk5 and ABL1 enzyme substrate 1 {ECO:0000313|EMBL:ACA05957.1}; GN Name=CABL1 {ECO:0000313|EMBL:ACA05957.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABL77400.1}; RN [1] {ECO:0000313|EMBL:ACA05957.1} RP NUCLEOTIDE SEQUENCE. RA Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N., Strausberg R.L., RA Kirkness E.F., Rogers Y.-H., Levy S.; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABL77400.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Endometrium {ECO:0000313|EMBL:ABL77400.1}; RX PubMed=18059193; DOI=10.4161/cbt.7.2.5253; RA Sakamoto H., Friel A.M., Wood A.W., Guo L., Ilic A., Seiden M.V., RA Chung D.C., Lynch M.P., Serikawa T., Munro E., Oliva E., Orsulic S., RA Kirley S.D., Foster R., Zukerberg L.R., Rueda B.R.; RT "Mechanisms of Cables 1 gene inactivation in human ovarian cancer RT development."; RL Cancer Biol. Ther. 7:180-188(2008). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF028204; ABL77400.1; -; mRNA. DR EMBL; EF444961; ACA05957.1; -; Genomic_DNA. DR RefSeq; NP_001094089.1; NM_001100619.2. DR AlphaFoldDB; A7K6Y5; -. DR SMR; A7K6Y5; -. DR Antibodypedia; 22022; 206 antibodies from 26 providers. DR DNASU; 91768; -. DR GeneID; 91768; -. DR KEGG; hsa:91768; -. DR CTD; 91768; -. DR DisGeNET; 91768; -. DR PharmGKB; PA134880184; -. DR VEuPathDB; HostDB:ENSG00000134508; -. DR HOGENOM; CLU_021942_2_0_1; -. DR OMA; EQWQLPR; -. DR OrthoDB; 209340at2759; -. DR BioGRID-ORCS; 91768; 22 hits in 1166 CRISPR screens. DR ChiTaRS; CABLES1; human. DR GenomeRNAi; 91768; -. DR ExpressionAtlas; A7K6Y5; baseline and differential. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0007399; P:nervous system development; IEA:TreeGrafter. DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro. DR CDD; cd20602; CYCLIN_CABLES1; 1. DR Gene3D; 1.10.472.10; Cyclin-like; 1. DR InterPro; IPR012388; CABLES1/2. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR006671; Cyclin_N. DR PANTHER; PTHR22896; CDK5 AND ABL1 ENZYME SUBSTRATE 1; 1. DR PANTHER; PTHR22896:SF1; CDK5 AND ABL1 ENZYME SUBSTRATE 1; 1. DR Pfam; PF00134; Cyclin_N; 1. DR PIRSF; PIRSF025798; Cables; 2. DR SUPFAM; SSF47954; Cyclin-like; 1. PE 2: Evidence at transcript level; FT DOMAIN 528..615 FT /note="Cyclin N-terminal" FT /evidence="ECO:0000259|Pfam:PF00134" FT REGION 1..99 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 10..29 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 30..52 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 633 AA; 67599 MW; D3569C6BFF635A82 CRC64; MAAAAAAATT AACSSGSAGT DAAGASGLQQ PPPQPQPQPA AAAPAQPPPE PPRKPRMDPR RRQAALSFLT NISLDGRLPP QDAEWGGGEE GGAAKPGAGG ACGARTRFSL LAAAERGGCI ALAAPGTPAA GLAAGSGPCL PQPSSLPPLI PGGHATVSGP GVARGFASPL GAGRASGEQW QPPRPAPLAA CAQLQLLDGS GAAGQEELEE DDAFISVQVP AAAFLGSGTP GSGSGSRGRL NSFTQGILPI AFSRPTSQNY CSLEQPGQGG STSAFEQLQR SRRRLISQRS SLETLEDIEE NAPLRRCRTL SGSPRPKNFK KIHFIKNMRQ HDTRNGRIVL ISGRRSFCSI FSVLPYRDST QVGDLKLDGG RQSTGAVSLK EIIGLEGVEL GADGKTVSYT QFLLPTNAFG ARRNTIDSTS SFSQFRNLSH RSLSIGRASG TQGSLDTGSD LGDFMDYDPN LLDDPQWPCG KHKRVLIFPS YMTTVIDYVK PSDLKKDMNE TFKEKFPHIK LTLSKIRSLK REMRKLAQED CGLEEPTVAM AFVYFEKLAL KGKLNKQNRK LCAGACVLLA AKIGSDLKKH EVKHLIDKLE EKFRLNRREL IAFEFPVLVA LEFALHLPEH EVMPHYRRLV QSS //