ID A6XLC9_THUAL Unreviewed; 326 AA. AC A6XLC9; DT 21-AUG-2007, integrated into UniProtKB/TrEMBL. DT 21-AUG-2007, sequence version 1. DT 15-JAN-2008, entry version 4. DE Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment). GN Name=COI; OS Thunnus albacares (Yellowfin tuna) (Neothunnus macropterus). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Scombroidei; OC Scombridae; Thunnus. OX NCBI_TaxID=8236; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=YFT6; RA Paine M.A., McDowell J.R., Graves J.E.; RT "Specific identification of western Atlantic Ocean scombrids using RT mitochondrial DNA cytochrome c oxidase subunit I (COI) gene region RT sequences."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Respiratory chain; terminal step. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ835949; ABI94344.1; -; Genomic_DNA. DR InterPro; IPR000883; COX1. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Inner membrane; Membrane; KW Mitochondrion; Oxidoreductase; Respiratory chain; Transmembrane; KW Transport. FT NON_TER 1 1 FT NON_TER 326 326 SQ SEQUENCE 326 AA; 35436 MW; 311773BFEBAA9AB0 CRC64; VMIFFMVMPI MIGGFGNWLI PLMIGAPDMA FPRMNNMSFW LLPPSFLLLL ASSGVEAGAG TGWTVYPPLA GNLAHAGASV DLTIFSLHLA GVSSILGAIN FITTIINMKP AAISQYQTPL FVWAVLITAV LLLLSLPVLA AGITMLLTDR NLNTTFFDPA GGGDPILYQH LFWFFGHPEV YILILPGFGM ISHIVAYYSG KKEPFGYMGM VWAMMAIGLL GFIVWAHHMF TVGMDVDTRA YFTSATMIIA IPTGVKVFSW LATLHGGAVK WETPLLWAIG FIFLFTVGGL TGIVLANSSL DIVLHDTYYV VAHFHYVLSM GAVFAI //