ID   A6XLC9_THUAL            Unreviewed;       326 AA.
AC   A6XLC9;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   28-NOV-2012, entry version 26.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=1.9.3.1;
DE   Flags: Fragment;
GN   Name=COI;
OS   Thunnus albacares (Yellowfin tuna) (Neothunnus macropterus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Scombroidei;
OC   Scombridae; Thunnus.
OX   NCBI_TaxID=8236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YFT6;
RA   Paine M.A., McDowell J.R., Graves J.E.;
RT   "Specific identification of western Atlantic Ocean scombrids using
RT   mitochondrial DNA cytochrome c oxidase subunit I (COI) gene region
RT   sequences.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR   EMBL; DQ835949; ABI94344.1; -; Genomic_DNA.
DR   HOVERGEN; HBG003841; -.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.210.10; COX1; 1.
DR   InterPro; IPR000883; Cyt_c_Oxase_su1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; COX1; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transport.
FT   NON_TER       1      1
FT   NON_TER     326    326
SQ   SEQUENCE   326 AA;  35436 MW;  311773BFEBAA9AB0 CRC64;
     VMIFFMVMPI MIGGFGNWLI PLMIGAPDMA FPRMNNMSFW LLPPSFLLLL ASSGVEAGAG
     TGWTVYPPLA GNLAHAGASV DLTIFSLHLA GVSSILGAIN FITTIINMKP AAISQYQTPL
     FVWAVLITAV LLLLSLPVLA AGITMLLTDR NLNTTFFDPA GGGDPILYQH LFWFFGHPEV
     YILILPGFGM ISHIVAYYSG KKEPFGYMGM VWAMMAIGLL GFIVWAHHMF TVGMDVDTRA
     YFTSATMIIA IPTGVKVFSW LATLHGGAVK WETPLLWAIG FIFLFTVGGL TGIVLANSSL
     DIVLHDTYYV VAHFHYVLSM GAVFAI
//