ID A6T7D6_KLEP7 Unreviewed; 348 AA. AC A6T7D6; DT 21-AUG-2007, integrated into UniProtKB/TrEMBL. DT 21-AUG-2007, sequence version 1. DT 04-DEC-2007, entry version 4. DE Dihydroorotase (EC 3.5.2.3). GN Name=pyrC; ORFNames=KPN_01074; OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH OS 78578). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=272620; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC 700721; RG The Klebsiella pneumonia Genome Sequencing Project; RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L- CC aspartate. CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity). CC -!- PATHWAY: Nucleotide biosynthesis; UMP biosynthesis; UMP from CC HCO(3)(-): step 3. CC -!- SIMILARITY: Belongs to the DHOase family. CC -!- SIMILARITY: Belongs to the DHOase family. Type 1 subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000647; ABR76507.1; -; Genomic_DNA. DR RefSeq; YP_001334737.1; -. DR GeneID; 5341622; -. DR InterPro; IPR006680; Amidohydro_1. DR InterPro; IPR004721; DHOdimr. DR InterPro; IPR002195; Dihydroorotase. DR Pfam; PF01979; Amidohydro_1; 1. DR TIGRFAMs; TIGR00856; pyrC_dimer; 1. DR PROSITE; PS00483; DIHYDROOROTASE_2; UNKNOWN_1. PE 3: Inferred from homology; KW Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc. SQ SEQUENCE 348 AA; 38821 MW; 2B841BB50B30506D CRC64; MTAQSQVLKI RRPDDWHIHL RDDDMLKTVV PYTSEFYGRA IVMPNLVPPV TTVAAAIAYR QRIMDAVPAG HDFTPLMTCY LTDSLDPAEL ERGFNEGVFT AAKLYPANAT TNSSHGVTST DAIMPVLERM EKLGMPLLVH GEVTHAEIDI FDREARFIET VMEPLRQRLP GLKVVFEHIT TKDAAEYVRD GNELLAATIT PQHLMFNRNH MLVGGIRPHL YCLPVLKRNI HQQALRELVA SGFSRAFLGT DSAPHARHRK EASCGCAGCF NAPTALGSYA TVFEEMNALQ HFEAFCSLNG PRFYGLPVNE SYVELVREET TVVDSIALPN DTLVPFLAGE TVRWTVKK //