ID SNTAN_HUMAN Reviewed; 147 AA. AC A6NMZ2; B7FF65; DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 24-JUL-2007, sequence version 1. DT 22-FEB-2023, entry version 99. DE RecName: Full=Sentan; DE AltName: Full=Protein S100-A1-like; DE AltName: Full=S100 calcium-binding protein A1-like; GN Name=SNTN; Synonyms=S100A1L; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Nasopharynx; RX PubMed=15289893; RA Liu X.-Q., Zhou Y., Zhang L.-J., Xu H., Chen H.-K., Pan Z.-G., Zeng Y.-X.; RT "Transcriptional gene expression profile of human nasopharynx."; RL Int. J. Mol. Med. 14:409-420(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [3] RP IDENTIFICATION. RX PubMed=18829862; DOI=10.1091/mbc.e08-07-0691; RA Kubo A., Yuba-Kubo A., Tsukita S., Tsukita S., Amagai M.; RT "Sentan: a novel specific component of the apical structure of vertebrate RT motile cilia."; RL Mol. Biol. Cell 19:5338-5346(2008). CC -!- FUNCTION: May be a component of the linker structure that bridges the CC ciliary membrane and peripheral singlet microtubules. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. CC Note=Expressed exclusively at the cilium tip where it localizes between CC the cell membrane and peripheral A-subfibers. {ECO:0000250}. CC -!- MISCELLANEOUS: 'Sentan' means 'tip' in Japanese. CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CD690073; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC136289; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BR000723; FAA00429.1; -; mRNA. DR CCDS; CCDS33779.1; -. DR RefSeq; NP_001074006.1; NM_001080537.1. DR AlphaFoldDB; A6NMZ2; -. DR SMR; A6NMZ2; -. DR STRING; 9606.ENSP00000341442; -. DR iPTMnet; A6NMZ2; -. DR PhosphoSitePlus; A6NMZ2; -. DR BioMuta; SNTN; -. DR MassIVE; A6NMZ2; -. DR PaxDb; A6NMZ2; -. DR PeptideAtlas; A6NMZ2; -. DR ProteomicsDB; 1571; -. DR Antibodypedia; 50719; 16 antibodies from 6 providers. DR DNASU; 132203; -. DR Ensembl; ENST00000343837.8; ENSP00000341442.3; ENSG00000188817.8. DR GeneID; 132203; -. DR KEGG; hsa:132203; -. DR MANE-Select; ENST00000343837.8; ENSP00000341442.3; NM_001080537.2; NP_001074006.1. DR UCSC; uc003dlr.4; human. DR AGR; HGNC:33706; -. DR CTD; 132203; -. DR DisGeNET; 132203; -. DR GeneCards; SNTN; -. DR HGNC; HGNC:33706; SNTN. DR HPA; ENSG00000188817; Tissue enriched (fallopian). DR MIM; 617832; gene. DR neXtProt; NX_A6NMZ2; -. DR OpenTargets; ENSG00000188817; -. DR PharmGKB; PA164726205; -. DR VEuPathDB; HostDB:ENSG00000188817; -. DR eggNOG; ENOG502S6AH; Eukaryota. DR GeneTree; ENSGT00390000003322; -. DR InParanoid; A6NMZ2; -. DR OMA; CTHSTQD; -. DR OrthoDB; 5352764at2759; -. DR PhylomeDB; A6NMZ2; -. DR TreeFam; TF335855; -. DR PathwayCommons; A6NMZ2; -. DR BioGRID-ORCS; 132203; 16 hits in 1138 CRISPR screens. DR ChiTaRS; SNTN; human. DR GenomeRNAi; 132203; -. DR Pharos; A6NMZ2; Tdark. DR PRO; PR:A6NMZ2; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; A6NMZ2; protein. DR Bgee; ENSG00000188817; Expressed in bronchial epithelial cell and 95 other tissues. DR ExpressionAtlas; A6NMZ2; baseline and differential. DR Genevisible; A6NMZ2; HS. DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central. DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central. DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro. DR CDD; cd00213; S-100; 1. DR Gene3D; 1.10.238.10; EF-hand; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR034325; S-100_dom. DR InterPro; IPR013787; S100_Ca-bd_sub. DR PANTHER; PTHR11639:SF134; PROTEIN S100-A1-RELATED; 1. DR PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1. DR SMART; SM01394; S_100; 1. DR SUPFAM; SSF47473; EF-hand; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Reference proteome. FT CHAIN 1..147 FT /note="Sentan" FT /id="PRO_0000342516" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 147 AA; 16468 MW; F1813E10E7BA5D13 CRC64; MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK //