ID SNTAN_HUMAN Reviewed; 147 AA. AC A6NMZ2; B7FF65; DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 24-JUL-2007, sequence version 1. DT 16-JAN-2019, entry version 80. DE RecName: Full=Sentan; DE AltName: Full=Protein S100-A1-like; DE AltName: Full=S100 calcium-binding protein A1-like; GN Name=SNTN; Synonyms=S100A1L; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Nasopharynx; RX PubMed=15289893; RA Liu X.-Q., Zhou Y., Zhang L.-J., Xu H., Chen H.-K., Pan Z.-G., RA Zeng Y.-X.; RT "Transcriptional gene expression profile of human nasopharynx."; RL Int. J. Mol. Med. 14:409-420(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [3] RP IDENTIFICATION. RX PubMed=18829862; DOI=10.1091/mbc.E08-07-0691; RA Kubo A., Yuba-Kubo A., Tsukita S., Tsukita S., Amagai M.; RT "Sentan: a novel specific component of the apical structure of RT vertebrate motile cilia."; RL Mol. Biol. Cell 19:5338-5346(2008). CC -!- FUNCTION: May be a component of the linker structure that bridges CC the ciliary membrane and peripheral singlet microtubules. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. CC Note=Expressed exclusively at the cilium tip where it localizes CC between the cell membrane and peripheral A-subfibers. CC {ECO:0000250}. CC -!- MISCELLANEOUS: 'Sentan' means 'tip' in Japanese. CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CD690073; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC136289; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BR000723; FAA00429.1; -; mRNA. DR CCDS; CCDS33779.1; -. DR RefSeq; NP_001074006.1; NM_001080537.1. DR UniGene; Hs.130704; -. DR ProteinModelPortal; A6NMZ2; -. DR SMR; A6NMZ2; -. DR iPTMnet; A6NMZ2; -. DR PhosphoSitePlus; A6NMZ2; -. DR BioMuta; SNTN; -. DR PaxDb; A6NMZ2; -. DR PRIDE; A6NMZ2; -. DR ProteomicsDB; 1571; -. DR Ensembl; ENST00000343837; ENSP00000341442; ENSG00000188817. DR GeneID; 132203; -. DR KEGG; hsa:132203; -. DR UCSC; uc003dlr.4; human. DR CTD; 132203; -. DR EuPathDB; HostDB:ENSG00000188817.7; -. DR GeneCards; SNTN; -. DR H-InvDB; HIX0024397; -. DR HGNC; HGNC:33706; SNTN. DR HPA; HPA043322; -. DR HPA; HPA058399; -. DR MIM; 617832; gene. DR neXtProt; NX_A6NMZ2; -. DR OpenTargets; ENSG00000188817; -. DR PharmGKB; PA164726205; -. DR eggNOG; ENOG410IX65; Eukaryota. DR eggNOG; ENOG41116AU; LUCA. DR GeneTree; ENSGT00390000003322; -. DR HOGENOM; HOG000154359; -. DR InParanoid; A6NMZ2; -. DR OrthoDB; 1529608at2759; -. DR PhylomeDB; A6NMZ2; -. DR TreeFam; TF335855; -. DR ChiTaRS; SNTN; human. DR GenomeRNAi; 132203; -. DR PRO; PR:A6NMZ2; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000188817; Expressed in 74 organ(s), highest expression level in bronchial epithelial cell. DR ExpressionAtlas; A6NMZ2; baseline and differential. DR Genevisible; A6NMZ2; HS. DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell. DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro. DR CDD; cd00213; S-100; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR034325; S-100_dom. DR InterPro; IPR013787; S100_Ca-bd_sub. DR InterPro; IPR026790; Sentan. DR PANTHER; PTHR11639:SF24; PTHR11639:SF24; 1. DR SMART; SM01394; S_100; 1. DR SUPFAM; SSF47473; SSF47473; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Complete proteome; Reference proteome. FT CHAIN 1 147 Sentan. FT /FTId=PRO_0000342516. SQ SEQUENCE 147 AA; 16468 MW; F1813E10E7BA5D13 CRC64; MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK //