ID OOEP_HUMAN Reviewed; 149 AA. AC A6NGQ2; A6NIN5; A9UIB7; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 01-SEP-2009, entry version 19. DE RecName: Full=Oocyte-expressed protein homolog; DE AltName: Full=Oocyte- and embryo-specific protein 19; DE AltName: Full=HOEP19; DE AltName: Full=KH homology domain-containing protein 2; GN Name=OOEP; Synonyms=C6orf156, KHDC2, OEP19; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Chertihin O., Herr J.C.; RT "Human oocyte and embryo protein (HOEP19)."; RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-92. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP IDENTIFICATION. RX PubMed=17913455; DOI=10.1016/j.ygeno.2007.06.003; RA Pierre A., Gautier M., Callebaut I., Bontoux M., Jeanpierre E., RA Pontarotti P., Monget P.; RT "Atypical structure and phylogenomic evolution of the new eutherian RT oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family."; RL Genomics 90:583-594(2007). CC -!- FUNCTION: As a member of the subcortical maternal complex (SCMC), CC plays an essential role for zygotes to progress beyond the first CC embryonic cell divisions (By similarity). CC -!- SUBUNIT: Within SCMC, directly interacts with NLRP5 and TLE6 (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=In the CC subcortical cytoplasm of early embryos from the 1-cell to the CC blastocyst stages. From the 2-cell stage, still detected in the CC subcortex, but excluded from cell-cell contact regions (By CC similarity). CC -!- DOMAIN: Contains an atypical KH domain with amino acid changes at CC critical sites, suggesting that it may not bind RNA. CC -!- SIMILARITY: Belongs to the KHDC1 family. CC -!- SIMILARITY: Contains 1 KH domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU290647; ABX84389.1; -; mRNA. DR EMBL; AC019205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR IPI; IPI00455726; -. DR RefSeq; NP_001073976.1; -. DR UniGene; Hs.671212; -. DR STRING; A6NGQ2; -. DR Ensembl; ENST00000370359; ENSP00000359384; ENSG00000203907; Homo sapiens. DR GeneID; 441161; -. DR KEGG; hsa:441161; -. DR UCSC; uc003pgu.2; human. DR CTD; 441161; -. DR GeneCards; GC06M074137; -. DR HGNC; HGNC:21382; OOEP. DR MIM; 611689; gene. DR NextBio; 109839; -. DR Bgee; A6NGQ2; -. DR CleanEx; HS_OOEP; -. DR PROSITE; PS50084; KH_TYPE_1; FALSE_NEG. PE 2: Evidence at transcript level; KW Complete proteome; Cytoplasm; Polymorphism. FT CHAIN 1 149 Oocyte-expressed protein homolog. FT /FTId=PRO_0000328802. FT DOMAIN 49 110 KH; atypical. FT VARIANT 18 18 A -> T (in dbSNP:rs2280286). FT /FTId=VAR_042523. FT VARIANT 92 92 A -> V (in dbSNP:rs496530). FT /FTId=VAR_042524. SQ SEQUENCE 149 AA; 17142 MW; E7D031FB51879404 CRC64; MVDDAGAAES QRGKQTPAHS LEQLRRLPLP PPQIRIRPWW FPVQELRDPL VFYLEAWLAD ELFGPDRAII PEMEWTSQAL LTVDIVDSGN LAEITVFGRP RVQNRVKSML LCLAWFHREH RARAEKMKHL EKNLKAHASD PHSPQDPVA //