ID A6MW64_9HEPC Unreviewed; 570 AA. AC A6MW64; DT 24-JUL-2007, integrated into UniProtKB/TrEMBL. DT 24-JUL-2007, sequence version 1. DT 19-JAN-2022, entry version 48. DE RecName: Full=RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363062}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363062}; DE Flags: Fragment; OS Hepacivirus C. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; OC Amarillovirales; Flaviviridae; Hepacivirus. OX NCBI_TaxID=11103 {ECO:0000313|EMBL:ABR18855.1}; RN [1] {ECO:0000313|EMBL:ABR18855.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=3a {ECO:0000313|EMBL:ABR18855.1}; RX PubMed=17459932; DOI=10.1128/JVI.01543-06; RA Pauwels F., Mostmans W., Quirynen L.M., van der Helm L., Boutton C.W., RA Rueff A.S., Cleiren E., Raboisson P., Surleraux D., Nyanguile O., RA Simmen K.A.; RT "Binding-site identification and genotypic profiling of hepatitis C virus RT polymerase inhibitors."; RL J. Virol. 81:6909-6919(2007). CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; CC EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU363062}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF523598; ABR18855.1; -; Genomic_RNA. DR euHCVdb; EF523598; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 3.30.70.270; -; 2. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR002166; RNA_pol_HCV. DR Pfam; PF00998; RdRP_3; 1. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|ARBA:ARBA00022510}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|ARBA:ARBA00022506}; Hydrolase {ECO:0000256|ARBA:ARBA00022825}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU363062}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, KW ECO:0000256|RuleBase:RU363062}; Protease {ECO:0000256|ARBA:ARBA00022825}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484, KW ECO:0000256|RuleBase:RU363062}; KW Serine protease {ECO:0000256|ARBA:ARBA00022825}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363062}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022506}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953, KW ECO:0000256|RuleBase:RU363062}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022506}. FT DOMAIN 214..332 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT COILED 68..88 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABR18855.1" FT NON_TER 570 FT /evidence="ECO:0000313|EMBL:ABR18855.1" SQ SEQUENCE 570 AA; 63626 MW; ACBFB9724E751948 CRC64; SMSYSWTGAL ITPCSAEEEK LPISPLSNSL LRHRNLVYST SSRSASQRQK KVTFDRLQVL DDHYKTALQE VKERASRVKA RMLTIEEACA LVPPHSARSK FGYSAKDVRS LSSKAINQIR SVWEDLLEGT TTPIPTTIMA KNEVFCVDPA KGGRKPARLI VYPDLGVRVC EKRALYDVIQ KLSIETMGSA YGFQYSPQQR VEHLLQMWTS KKTPLGFSYD TRCFDSTVTE QDIRVEEEIY QCCNLEPEAR KVISSLTERL YCGGPMFNSK GAQCGYRRCR ASGVLPTSFG NTITCYIKAS AAARAAGLRN PDFLVCGDDL VVVAESDGVD EDRATLRAFT EAMTRYSAPP GDAPQPTYDL ELITSCSSNV SVARDDKGKR YYYLTRDATT PLARAAWETA RHTPVNSWLG NIIMYAPTIW VRMVMMTHFF SILQSQEILD RPLDFEMYGA TYSVTPLDLP AIIERLHGLS AFTLHSYSPV ELNRVAGTLR KLGCPPLRAW RHRARAVRAK LIAQGGKAKT CGLYLFNWAV RTKAKLTPLP AAGQLDLSSW FTVGVGGNDI YHSVSRARTR //