ID A6MW64_9HEPC Unreviewed; 570 AA. AC A6MW64; DT 24-JUL-2007, integrated into UniProtKB/TrEMBL. DT 24-JUL-2007, sequence version 1. DT 11-JUL-2012, entry version 15. DE SubName: Full=Polyprotein; DE Flags: Fragment; OS Hepatitis C virus. OC Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; OC Hepacivirus. OX NCBI_TaxID=11103; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=3a; RX PubMed=17459932; DOI=10.1128/JVI.01543-06; RA Pauwels F., Mostmans W., Quirynen L.M., van der Helm L., Boutton C.W., RA Rueff A.S., Cleiren E., Raboisson P., Surleraux D., Nyanguile O., RA Simmen K.A.; RT "Binding-site identification and genotypic profiling of hepatitis C RT virus polymerase inhibitors."; RL J. Virol. 81:6909-6919(2007). CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). CC -!- SIMILARITY: Contains 1 RdRp catalytic domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF523598; ABR18855.1; -; Genomic_RNA. DR ProteinModelPortal; A6MW64; -. DR euHCVdb; EF523598; -. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR002166; RNA_pol_HCV. DR Pfam; PF00998; RdRP_3; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Nucleotide-binding; Nucleotidyltransferase; KW RNA-directed RNA polymerase; Transferase; Viral RNA replication. FT CHAIN <1 >570 non-structural protein 5B. FT /FTId=PRO_5000254152. FT NON_TER 1 1 FT NON_TER 570 570 SQ SEQUENCE 570 AA; 63626 MW; ACBFB9724E751948 CRC64; SMSYSWTGAL ITPCSAEEEK LPISPLSNSL LRHRNLVYST SSRSASQRQK KVTFDRLQVL DDHYKTALQE VKERASRVKA RMLTIEEACA LVPPHSARSK FGYSAKDVRS LSSKAINQIR SVWEDLLEGT TTPIPTTIMA KNEVFCVDPA KGGRKPARLI VYPDLGVRVC EKRALYDVIQ KLSIETMGSA YGFQYSPQQR VEHLLQMWTS KKTPLGFSYD TRCFDSTVTE QDIRVEEEIY QCCNLEPEAR KVISSLTERL YCGGPMFNSK GAQCGYRRCR ASGVLPTSFG NTITCYIKAS AAARAAGLRN PDFLVCGDDL VVVAESDGVD EDRATLRAFT EAMTRYSAPP GDAPQPTYDL ELITSCSSNV SVARDDKGKR YYYLTRDATT PLARAAWETA RHTPVNSWLG NIIMYAPTIW VRMVMMTHFF SILQSQEILD RPLDFEMYGA TYSVTPLDLP AIIERLHGLS AFTLHSYSPV ELNRVAGTLR KLGCPPLRAW RHRARAVRAK LIAQGGKAKT CGLYLFNWAV RTKAKLTPLP AAGQLDLSSW FTVGVGGNDI YHSVSRARTR //